Cloned (Comment) | Organism |
---|---|
gene lsrK, encoded in the lsrKR operon where lsrK codes for an AI-2 kinase and lsrR encodes a repressor of the lsr operon, sequences important for the optimal transcription of lsrRK are located between -89 and -255 bp. LsrR regulates the expression of both lsrACDBFG and lsrRK operons. Transcription of the lsr locus is complex and may be driven by several promoters | Aggregatibacter actinomycetemcomitans |
Protein Variants | Comment | Organism |
---|---|---|
additional information | generation of chromosomal lsrK deletion (DELTAlsrK), or a chromosomal lsrRK double-deletion (DELTAlsrRK), the transcriptional activities of lsrR-P and lsrA-P do not differ significantly in the wild-type and lsrK-deficient backgrounds, while in the absence of LsrR, the transcriptional activity of both lsrR-P and lsrA-P is increased relative to that of the wild-type strain | Aggregatibacter actinomycetemcomitans |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | rrequired | Aggregatibacter actinomycetemcomitans |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + autoinducer-2 | Aggregatibacter actinomycetemcomitans | i.e. AI-2 | ADP + phosphorylated autoinducer-2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Aggregatibacter actinomycetemcomitans | - |
gene lsrK in the lsrRK operon | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + autoinducer-2 | i.e. AI-2 | Aggregatibacter actinomycetemcomitans | ADP + phosphorylated autoinducer-2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
AI-2 kinase | - |
Aggregatibacter actinomycetemcomitans |
lsrK | - |
Aggregatibacter actinomycetemcomitans |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Aggregatibacter actinomycetemcomitans |
Organism | Comment | Expression |
---|---|---|
Aggregatibacter actinomycetemcomitans | LsrR regulates the expression of both lsrACDBFG and lsrRK operons | additional information |
General Information | Comment | Organism |
---|---|---|
physiological function | genes lsrK and crp are required for optimal biofilm formation by Aggregatibacter actinomycetemcomitans. Another kinase is capable of phosphorylating AI-2 in Aggregatibacter actinomycetemcomitans in the absence of LsrK or enzyme LsrK is not essential for regulating the lsrACDBFG and lsrRK operons in AAggregatibacter actinomycetemcomitans | Aggregatibacter actinomycetemcomitans |