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Literature summary for 2.7.1.189 extracted from

  • Roy, V.; Fernandes, R.; Tsao, C.Y.; Bentley, W.E.
    Cross species quorum quenching using a native AI-2 processing enzyme (2010), ACS Chem. Biol., 5, 223-232.
    View publication on PubMed
Search for more literature for 2.7.1.189

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + autoinducer-2 Escherichia coli
-
 ADP + phosphorylated autoinducer-2
-
 ?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
 gene lsrK
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + autoinducer-2
-
 Escherichia coli ADP + phosphorylated autoinducer-2
-
 ?
ATP + autoinducer-2 i.e. AI-2 Escherichia coli ADP + phosphorylated autoinducer-2
-
 ?

Synonyms

Synonyms Comment Organism
AI-2 kinase
-
 Escherichia coli
lsrK
-
 Escherichia coli

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Escherichia coli

General Information

General Information Comment Organism
additional information LsrK-mediated degradation of autoinducer-2 attenuates the quorum sensing response among Salmonella typhimurium and Vibrio harveyi even though the autoinducer-2 signal transduction mechanisms and the phenotypic responses are species-specific Escherichia coli
physiological function when enzyme-treated autoinducer-2 is added ex vivo to Escherichia coli populations, the native quorum sensing response is significantly reduced, overview. The addition of enzyme LsrK and ATP to growing co-cultures of Escherichia coli and Salmonella typhimurium exhibits significantly reduced native cross-talk that ordinarily exists among and between species in an ecosystem Escherichia coli