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Literature summary for 2.7.1.187 extracted from

  • Zhang, C.S.; Stratmann, A.; Block, O.; Brückner, R.; Podeschwa, M.; Altenbach, H.J.; Wehmeier, U.F.; Piepersberg, W.
    Biosynthesis of the C(7)-cyclitol moiety of acarbose in Actinoplanes species SE50/110. 7-O-Phosphorylation of the initial cyclitol precursor leads to proposal of a new biosynthetic pathway (2002), J. Biol. Chem., 277, 22853-22862.
    View publication on PubMed
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Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Actinoplanes sp.

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + acarbose Actinoplanes sp.
-
 ADP + acarbose 7'''-phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Actinoplanes sp. Q8RMD4
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + acarbose
-
 Actinoplanes sp. ADP + acarbose 7'''-phosphate
-
 ?
ATP + acarbose the enzyme does not use monomeric cyclitol precursors as substrates. No activity with 2-epi-5-epi-valiolone, 2-epi-5-epi-valiolol, 1-epi-2-epi-5-epi-valiolol, 1-epi-5-epi-valiolol, 5-epi-valiolol, 1-epi-valienol, valienol Actinoplanes sp. ADP + acarbose 7'''-phosphate
-
 ?

Synonyms

Synonyms Comment Organism
AcbK
-
 Actinoplanes sp.