Literature summary for 2.7.1.176 extracted from

Lioy, V.S.; Machon, C.; Tabone, M.; Gonzalez-Pastor, J.E.; Daugelavicius, R.; Ayora, S.; Alonso, J.C.
The zeta toxin induces a set of protective responses and dormancy (2012), PLoS ONE, 7, e30282.

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Activating Compound

Activating Compound	Comment	Organism	Structure
RelA	contributes to enforce toxin-induced dormanc. After induction of the zetaY83C toxin the expression of the relA gene is induced. Disruption of RelA is pleotropic, leading to poor growth and accumulation of phenotypic suppressors that increase expression of the other (p)ppGpp synthetase genes, ssa1 and ssa2	Bacillus subtilis

Cloned(Commentary)

Cloned (Comment)	Organism
expression of zeta toxin in Escherichia coli under control of the LacI repressor-Hyper-Spank promoter using vector pDR111	Bacillus subtilis

Protein Variants

Protein Variants	Comment	Organism
Y83C	site-directed mutagenesis, the mutant induces the dormant state with equal efficiency as the wild-type toxin independently of the KCl concentration of 5-150 mM. zetaY83C-induced dormancy is characterized by minimal metabolism, with the repression of genes involved in glycolysis such as yqeC, mtlD, glpK, glpD, yvkC, gutP, gntK, gntR, and gntZ. zetaY83C toxin induction also affects ATP and GTP production levels, overview	Bacillus subtilis

Organism

Organism	UniProt	Comment	Textmining
Bacillus subtilis	-	and several other isogenic strains	-
Bacillus subtilis BG214	-	and several other isogenic strains	-

Synonyms

Synonyms	Comment	Organism
toxin zeta	-	Bacillus subtilis

General Information

General Information	Comment	Organism
physiological function	toxin zeta inhibits cell wall biosynthesis and may be bactericide in nature, it induces at or near physiological concentrations reversible cessation of Bacillus subtilis proliferation, as protective dormancy, by targeting essential metabolic functions and selects a subpopulation of cells that exhibit non-inheritable tolerance. zeta Toxin induces reversible protective dormancy and permeation to propidium iodide, and expression of epsilon2 antitoxin reverses these effects. At later times, free active zeta decreases synthesis of macromolecules and releases intracellular K+, molecular mechanisms and regulation, overview	Bacillus subtilis

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Release 2023.1 (January 2023)