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Literature summary for 2.7.1.176 extracted from

  • Zielenkiewicz, U.; Ceglowski, P.
    The toxin-antitoxin system of the streptococcal plasmid pSM19035 (2005), J. Bacteriol., 187, 6094-6105.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.1.176

Cloned(Commentary)

Cloned (Comment) Organism
the gene is encoded in plasmid pSM19035. The omega-epsilon-zeta operon of this plasmid constitutes a proteic plasmid addiction system in which the epsilon and zeta genes encode an antitoxin and toxin, respectively, while omega plays an autoregulatory function Streptococcus pyogenes

Protein Variants

Protein Variants Comment Organism
A111C deletion of one A in the AAAAAAA tract, which begins at the 78-nt position, results in a frameshift and the stop codon formation after 51 codons, additional mutations are insertion of G after A32 and A111C substitution in one case and A248G substitution in the second one Streptococcus pyogenes
A248G deletion of one A in the AAAAAAA tract, which begins at the 78-nt position, results in a frameshift and the stop codon formation after 51 codons, additional mutations are insertion of G after A32 and A111C substitution in one case and A248G substitution in the second one Streptococcus pyogenes

Organism

Organism UniProt Comment Textmining
Streptococcus pyogenes Q54944 the gene is encoded in plasmid pSM19035
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Synonyms

Synonyms Comment Organism
toxin zeta
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 Streptococcus pyogenes

General Information

General Information Comment Organism
physiological function toxin zeta is bactericidal for the gram-positive Bacillus subtilis and bacteriostatic for the gram-negative Escherichia coli, counteracted by proper expression of epsilon. Functioning of the omega-epsilon-zeta operon as a stabilizing cassette in Bacillus subtilis and Escherichia coli cells, mechanism, overview Streptococcus pyogenes