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Literature summary for 2.7.1.173 extracted from

  • Zamporlini, F.; Ruggieri, S.; Mazzola, F.; Amici, A.; Orsomando, G.; Raffaelli, N.
    Novel assay for simultaneous measurement of pyridine mononucleotides synthesizing activities allows dissection of the NAD+ biosynthetic machinery in mammalian cells (2014), FEBS J., 281, 5104-5119.
    View publication on PubMed

Application

Application Comment Organism
diagnostics screening of tumors for NRK activity is necessary for the design of efficient NamPRT-targeted antitumor therapy Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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Source Tissue

Source Tissue Comment Organism Textmining
brain
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Homo sapiens
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heart
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Homo sapiens
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kidney
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Homo sapiens
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liver
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Homo sapiens
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lung
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Homo sapiens
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additional information ubiquitous expression of nicotinamide riboside kinase in tissues and cell lines Homo sapiens
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skeletal muscle
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Homo sapiens
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spleen
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Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + beta-D-ribosylnicotinate
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Homo sapiens ADP + nicotinate beta-D-ribonucleotide
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?
additional information development of a highly sensitive, rapid and specific coupled enzymatic assay that allows simultaneous determination of NRK activitiy, as well as of nicotinic acid phosphoribosyltransferase, quinolinic acid phosphoribosyltransferase, and nicotinamide phosphoribosyltransferase activities, in various biological samples of various origins, evaluation and optimization using liver extracts, overview Homo sapiens ?
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?

Synonyms

Synonyms Comment Organism
NR kinase
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Homo sapiens
Nrk
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Homo sapiens

General Information

General Information Comment Organism
metabolism distinct metabolic routes, starting from various precursors, are known to support NAD+ biosynthesis with tissue/cell-specific efficiencies, probably reflecting differential expression of the corresponding rate-limiting enzymes, i.e. nicotinamide phosphoribosyltransferase, quinolinate phosphoribosyltransferase, nicotinate phosphoribosyltransferase and nicotinamide riboside kinase Homo sapiens
physiological function nicotinamide riboside is a relevant NAD+ precursor Homo sapiens