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Literature summary for 2.7.1.173 extracted from

  • Belenky, P.; Christensen, K.C.; Gazzaniga, F.; Pletnev, A.A.; Brenner, C.
    Nicotinamide riboside and nicotinic acid riboside salvage in fungi and mammals. Quantitative basis for Urh1 and purine nucleoside phosphorylase function in NAD+ metabolism (2009), J. Biol. Chem., 284, 158-164.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.1.173

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + beta-D-ribosylnicotinamide Saccharomyces cerevisiae
-
 ADP + nicotinamide beta-D-ribonucleotide
-
 ?
ATP + beta-D-ribosylnicotinamide Saccharomyces cerevisiae BY4742
-
 ADP + nicotinamide beta-D-ribonucleotide
-
 ?

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + beta-D-ribosylnicotinamide
-
 Saccharomyces cerevisiae ADP + nicotinamide beta-D-ribonucleotide
-
 ?
ATP + beta-D-ribosylnicotinamide
-
 Saccharomyces cerevisiae BY4742 ADP + nicotinamide beta-D-ribonucleotide
-
 ?

Synonyms

Synonyms Comment Organism
nicotinamide riboside kinase
-
 Saccharomyces cerevisiae
Nrk
-
 Saccharomyces cerevisiae

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Saccharomyces cerevisiae

General Information

General Information Comment Organism
metabolism nicotinamide riboside elevates NAD+ levels via the nicotinamide riboside kinase pathway and by a pathway initiated by splitting the nucleoside into a nicotinamide base followed by nicotinamide salvage. Yeast nicotinic acid riboside utilization largely depends on uridine hydrolase and nicotinamide riboside kinase, and nicotinic acid riboside bioavailability is increased by ester modification Saccharomyces cerevisiae
additional information comparison to the Nrk-independent utilization pathway of nicotinamide riboside in yeast, overview Saccharomyces cerevisiae
physiological function nicotinamide riboside kinase increases the NAD+ levels via convertion of the substrate nicotinamide riboside and thereby extending replicative lifespan and increases Sir2-dependent gene silencing Saccharomyces cerevisiae