Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | FN3K activity is significantly correlated with HbA1c values, although the correlation between FN3K and HbA1c is weak | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
genotyping of FN3K SNP rs1056534 and the ferroportin SNP rs1156350. FN3K activity depends on the ferroportin Q248H genotypes, with the highest value for the wild-type genotype | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | neither transferrin saturation nor ferritin are confounders for the FN3K activity | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | required | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q9H479 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
blood serum | - |
Homo sapiens | - |
erythrocyte | - |
Homo sapiens | - |
additional information | enzyme FN3K activity is neither age- nor sex-dependent. The various FN3K SNP rs1056534 genotypes show no significant differences in serum FN3K activity. In diabetics, enzyme activity values are comparable to those of the controls. FN3K activity in erythrocytes is significantly higher | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
glycated bovine serum albumin + ATP | derived from dialyzed glycated bovine serum albumin | Homo sapiens | ? | - |
? | |
additional information | development of a simple colorimetric method for assaying FN3K activity in human body fluids | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
FN3K | - |
Homo sapiens |
fructosamine 3 kinase | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
25 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | fructosamine 3 kinase is a deglycating enzyme, which may play a key role in reducing diabetes-induced organ damage by removing bound glucose from glycated proteins | Homo sapiens |