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Literature summary for 2.7.1.171 extracted from

  • Cikomola, J.C.; Kishabongo, A.S.; Vandepoele, K.; Mulder, M.; Katchunga, P.B.; Laukens, B.; Schie, L.V.; Grootaert, H.; Callewaert, N.; Speeckaert, M.M.; Delanghe, J.R.
    A simple colorimetric assay for measuring fructosamine 3 kinase activity (2017), Clin. Chem. Lab. Med., 55, 154-159.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
additional information FN3K activity is significantly correlated with HbA1c values, although the correlation between FN3K and HbA1c is weak Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
genotyping of FN3K SNP rs1056534 and the ferroportin SNP rs1156350. FN3K activity depends on the ferroportin Q248H genotypes, with the highest value for the wild-type genotype Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information neither transferrin saturation nor ferritin are confounders for the FN3K activity Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9H479
-
-

Source Tissue

Source Tissue Comment Organism Textmining
blood serum
-
Homo sapiens
-
erythrocyte
-
Homo sapiens
-
additional information enzyme FN3K activity is neither age- nor sex-dependent. The various FN3K SNP rs1056534 genotypes show no significant differences in serum FN3K activity. In diabetics, enzyme activity values are comparable to those of the controls. FN3K activity in erythrocytes is significantly higher Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
glycated bovine serum albumin + ATP derived from dialyzed glycated bovine serum albumin Homo sapiens ?
-
?
additional information development of a simple colorimetric method for assaying FN3K activity in human body fluids Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
FN3K
-
Homo sapiens
fructosamine 3 kinase
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
25
-
assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
assay at Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
Homo sapiens

General Information

General Information Comment Organism
physiological function fructosamine 3 kinase is a deglycating enzyme, which may play a key role in reducing diabetes-induced organ damage by removing bound glucose from glycated proteins Homo sapiens