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Literature summary for 2.7.1.171 extracted from

  • Delpierrre, G.; Vertommen. D.; Communi, D.; Rider, M.H.; van Schaftingen, E.
    Identification of fructosamine residues deglycated by fructosamine-3-kinase in human hemoglobin (2004), J. Biol. Chem., 279, 27613-27620.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + [protein]-N6-D-fructosyl-L-lysine Homo sapiens fructosamine-3-kinase phosphorylates fructosamine residues, leading to their destabilization and their shedding from protein ADP + [protein]-N6-(O3-phosphono-D-fructosyl)-L-lysine
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Organism

Organism UniProt Comment Textmining
Homo sapiens
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Source Tissue

Source Tissue Comment Organism Textmining
erythrocyte
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Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + [hemoglobin]-N6-D-fructosyl-L-lysine mass-spectrometric identification of the fructosamine residues that are removed from hemoglobin in intact erythrocytes as a result of the action of fructosamine-3-kinase: Lys16, Lys61 and Lys139 in the alpha-chain of hemoglobin, Val1, Lys17, Lys59, Lys66, Lys132, and Lys144 in the beta-chain of hemoglobin. Some (e.g. Lys139 in the alph-chain of hemoglobin) are readily phosphorylated to a maximal extent by fructosamine-3-kinase in vitro whereas others (e.g. Val1 in the beta-chain of hemoglobin) are slowly and only very partially phosphorylated Homo sapiens ADP + [hemoglobin]-N6-(O3-phosphono-D-fructosyl)-L-lysine
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ATP + [protein]-N6-D-fructosyl-L-lysine fructosamine-3-kinase phosphorylates fructosamine residues, leading to their destabilization and their shedding from protein Homo sapiens ADP + [protein]-N6-(O3-phosphono-D-fructosyl)-L-lysine
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?

Synonyms

Synonyms Comment Organism
FN3K
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Homo sapiens
fructosamine-3-kinase
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Homo sapiens