Application | Comment | Organism |
---|---|---|
medicine | inhibition of fructoseamine-3-kinase is a promising new therapeutic target for diabetic complications, as well as other 3-deoxyglucosone-dependent pathologies | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
3-O-methylsorbitol-lysine | inhibitors based on sorbitol show competitive inhibition of the fructoseamine-3-kinase reaction but also prevent the formation of 3-deoxyglucosone, because there is no spontaneous decomposition of the product to 3-deoxyglucosone. For compounds blocked at C3, also there is no product formed. The Ki values of these compounds are approx. 0.5 mM. Although high for an in vivo drug, their apparent low toxicity make it possible to use them, at least in animals, to lower 3-deoxyglucosone levels | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [protein]-N6-D-fructosyl-L-lysine | Rattus norvegicus | fructoselysine 3-phosphate spontaneously decomposes to lysine, phosphate and 3-deoxyglucosone. This pathway appears to dominate 3-deoxyglucosone production in vivo, making it possible to modulate 3-deoxyglucosone levels by stimulating or inhibiting the reaction | ADP + [protein]-N6-(O3-phosphono-D-fructosyl)-L-lysine | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
SpragueDawley or Fisher 344. Rats carrying the Tsc2 gene (Eker rats) in a Fisher 344 background | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
blood plasma | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [protein]-N6-D-fructosyl-L-lysine | - |
Rattus norvegicus | ADP + [protein]-N6-(O3-phosphono-D-fructosyl)-L-lysine | fructoselysine 3-phosphate spontaneously decomposes to lysine, phosphate and 3-deoxyglucosone | ? | |
ATP + [protein]-N6-D-fructosyl-L-lysine | fructoselysine 3-phosphate spontaneously decomposes to lysine, phosphate and 3-deoxyglucosone. This pathway appears to dominate 3-deoxyglucosone production in vivo, making it possible to modulate 3-deoxyglucosone levels by stimulating or inhibiting the reaction | Rattus norvegicus | ADP + [protein]-N6-(O3-phosphono-D-fructosyl)-L-lysine | - |
? |
Synonyms | Comment | Organism |
---|---|---|
FL3P | - |
Rattus norvegicus |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
3-O-methylsorbitol-lysine | inhibitors based on sorbitol show competitive inhibition of the fructoseamine-3-kinase reaction but also prevent the formation of 3-deoxyglucosone, because there is no spontaneous decomposition of the product to 3-deoxyglucosone. For compounds blocked at C3, also there is no product formed. The Ki values of these compounds are approx. 0.5 mM. Although high for an in vivo drug, their apparent low toxicity make it possible to use them, at least in animals, to lower 3-deoxyglucosone levels | Rattus norvegicus |
Organism | Comment | Expression |
---|---|---|
Rattus norvegicus | mildly glycated casein in a standard diet stimulates 3-deoxyglucosone levels 1020fold in the plasma and approximately 3fold in the kidney compared with a control diet containing identical constituents | additional information |