Literature summary for 2.7.1.164 extracted from

Araiso, Y.; Sherrer, R.L.; Ishitani, R.; Ho, J.M.; S�ll, D.; Nureki, O.
Structure of a tRNA-dependent kinase essential for selenocysteine decoding (2009), Proc. Natl. Acad. Sci. USA, 106, 16215-16220.

Search for more literature for 2.7.1.164

Crystallization (Commentary)

Crystallization (Comment)	Organism
sitting drop vapor diffusion method at 20°C, the structures of MjPSTK complexed with ADP and AMPPNP revealed that this enzyme belongs to the P-loop kinase class, and that the kinase domain is closely related to gluconate kinase and adenylate kinase. ATP is bound by the P-loop domain (residues 11-18). Formed by antiparallel dimerization of two O-phosphoseryl-tRNASec kinase monomers, the enzyme structure shows a deep groove with positive electrostatic potential. Located in this groove is the active site of the enzyme, which biochemical and genetic data suggest is composed of Asp-41, Arg-44, Glu-55, Tyr-82, Tyr-83, Met-86, and Met-132	Methanocaldococcus jannaschii

Crystallization (Comment)

Organism

sitting drop vapor diffusion method at 20°C, the structures of MjPSTK complexed with ADP and AMPPNP revealed that this enzyme belongs to the P-loop kinase class, and that the kinase domain is closely related to gluconate kinase and adenylate kinase. ATP is bound by the P-loop domain (residues 11-18). Formed by antiparallel dimerization of two O-phosphoseryl-tRNASec kinase monomers, the enzyme structure shows a deep groove with positive electrostatic potential. Located in this groove is the active site of the enzyme, which biochemical and genetic data suggest is composed of Asp-41, Arg-44, Glu-55, Tyr-82, Tyr-83, Met-86, and Met-132

Methanocaldococcus jannaschii

Organism

Organism	UniProt	Comment	Textmining
Methanocaldococcus jannaschii	Q58933	-	-
Methanocaldococcus jannaschii DSM 2661	Q58933	-	-

Purification (Commentary)

Purification (Comment)	Organism
-	Methanocaldococcus jannaschii

Synonyms

Synonyms	Comment	Organism
O-phosphoseryl-tRNA(Sec) kinase	-	Methanocaldococcus jannaschii
PSTK	-	Methanocaldococcus jannaschii

General Information

General Information	Comment	Organism
physiological function	the enzyme is involved in the biosynthesis of selenocysteine	Methanocaldococcus jannaschii

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)