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Literature summary for 2.7.1.164 extracted from

  • Yuan, J.; Palioura, S.; Salazar, J.C.; Su, D.; O'Donoghue, P.; Hohn, M.J.; Cardoso, A.M.; Whitman, W.B.; Söll, D.
    RNA-dependent conversion of phosphoserine forms selenocysteine in eukaryotes and archaea (2006), Proc. Natl. Acad. Sci. USA, 103, 18923-18927.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.1.164

Cloned(Commentary)

Cloned (Comment) Organism
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 Methanocaldococcus jannaschii

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + seryl-tRNASec Methanocaldococcus jannaschii L-phosphoseryl-tRNA is the crucial precursor for L-selenocysteinyl-tRNA formation in archaea and eukarya. Selenocysteine formation is achieved by a two-step process: O-phosphoseryl-tRNASec kinase (PSTK) phosphorylates the endogenous Ser-tRNASec to O-phosphoseryl-tRNASec, and then this misacylated amino acid-tRNA species is converted to L-selenocysteinyl-tRNASec by Sep-tRNA:Sec-tRNA synthase (SepSecS) ADP + O-phospho-L-seryl-tRNASec
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 ?
ATP + seryl-tRNASec Methanocaldococcus jannaschii DSM 2661 L-phosphoseryl-tRNA is the crucial precursor for L-selenocysteinyl-tRNA formation in archaea and eukarya. Selenocysteine formation is achieved by a two-step process: O-phosphoseryl-tRNASec kinase (PSTK) phosphorylates the endogenous Ser-tRNASec to O-phosphoseryl-tRNASec, and then this misacylated amino acid-tRNA species is converted to L-selenocysteinyl-tRNASec by Sep-tRNA:Sec-tRNA synthase (SepSecS) ADP + O-phospho-L-seryl-tRNASec
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 ?

Organism

Organism UniProt Comment Textmining
Methanocaldococcus jannaschii Q58933
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Methanocaldococcus jannaschii DSM 2661 Q58933
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + L-seryl-tRNASec L-phosphoseryl-tRNA is the crucial precursor for L-selenocysteinyl-tRNA formation in archaea and eukarya. Selenocysteine formation is achieved by a two-step process: O-phosphoseryl-tRNASec kinase (PSTK) phosphorylates the endogenous Ser-tRNASec to O-phosphoseryl-tRNASec, and then this misacylated amino acid-tRNA species is converted to L-selenocysteinyl-tRNASec by Sep-tRNA:Sec-tRNA synthase (SepSecS) Methanocaldococcus jannaschii ADP + O-phospho-L-seryl-tRNASec
-
 ?
ATP + L-seryl-tRNASec L-phosphoseryl-tRNA is the crucial precursor for L-selenocysteinyl-tRNA formation in archaea and eukarya. Selenocysteine formation is achieved by a two-step process: O-phosphoseryl-tRNASec kinase (PSTK) phosphorylates the endogenous Ser-tRNASec to O-phosphoseryl-tRNASec, and then this misacylated amino acid-tRNA species is converted to L-selenocysteinyl-tRNASec by Sep-tRNA:Sec-tRNA synthase (SepSecS) Methanocaldococcus jannaschii DSM 2661 ADP + O-phospho-L-seryl-tRNASec
-
 ?
ATP + seryl-tRNASec L-phosphoseryl-tRNA is the crucial precursor for L-selenocysteinyl-tRNA formation in archaea and eukarya. Selenocysteine formation is achieved by a two-step process: O-phosphoseryl-tRNASec kinase (PSTK) phosphorylates the endogenous Ser-tRNASec to O-phosphoseryl-tRNASec, and then this misacylated amino acid-tRNA species is converted to L-selenocysteinyl-tRNASec by Sep-tRNA:Sec-tRNA synthase (SepSecS) Methanocaldococcus jannaschii ADP + O-phospho-L-seryl-tRNASec
-
 ?
ATP + seryl-tRNASec L-phosphoseryl-tRNA is the crucial precursor for L-selenocysteinyl-tRNA formation in archaea and eukarya. Selenocysteine formation is achieved by a two-step process: O-phosphoseryl-tRNASec kinase (PSTK) phosphorylates the endogenous Ser-tRNASec to O-phosphoseryl-tRNASec, and then this misacylated amino acid-tRNA species is converted to L-selenocysteinyl-tRNASec by Sep-tRNA:Sec-tRNA synthase (SepSecS) Methanocaldococcus jannaschii DSM 2661 ADP + O-phospho-L-seryl-tRNASec
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 ?

Synonyms

Synonyms Comment Organism
O-phosphoseryl-tRNASec kinase
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 Methanocaldococcus jannaschii
PSTK
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 Methanocaldococcus jannaschii