Literature summary for 2.7.1.159 extracted from

Zhang, C.; Majerus, P.W.; Wilson, M.P.
Regulation of inositol 1,3,4-trisphosphate 5/6-kinase (ITPK1) by reversible lysine acetylation (2012), Proc. Natl. Acad. Sci. USA, 109, 2290-2295.

Search for more literature for 2.7.1.159

Cloned(Commentary)

Cloned (Comment)	Organism
expression in Sf9 cells and HEK-293 cells	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
additional information	isoform ITPK1 can be acetylated by the acetyltransferases CREB-binding protein, CBP, and p300 both in vivo and in vitro and can be deacetylated by mammalian silent information regulator 2, SIRT1. Acetylation of ITPK1 decreases its enzyme activity and protein stability, and inhibits the synthesis of higher phosphorylated forms of inositol polyphosphates in the inositol signaling pathway. The acetylation sites are lysine residues 340, 383, and 410, which are all located on the surface of the protein	Homo sapiens

Synonyms

Synonyms	Comment	Organism
ITPK1	-	Homo sapiens

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)