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Literature summary for 2.7.1.159 extracted from

  • Verbsky, J.W.; Chang, S.C.; Wilson, M.P.; Mochizuki, Y.; Majerus, P.W.
    The pathway for the production of inositol hexakisphosphate in human cells (2005), J. Biol. Chem., 280, 1911-1920.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
stable overexpression in HEK-293 cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information enzyme silencing in HeLa cells decreases the levels of inositol pentakisphosphate and inositol hexakisphosphate, while overexpression in HEK-293 cells increases the levels of InsP4, InsP5, and InsP6, overview Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
KCl
-
Homo sapiens
Mg2+
-
Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens regulation of enzymes involved in the inositol phosphate metabolism in human cells, overview ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HeLa cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 1D-myo-inositol-1,3,4,6-tetrakisphosphate
-
Homo sapiens ADP + 1D-myo-inositol-1,3,4,5,6-pentakisphosphate
-
?
additional information regulation of enzymes involved in the inositol phosphate metabolism in human cells, overview Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
Ins(1,3,4)P3 5/6-kinase
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.2
-
assay at Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
Homo sapiens