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Literature summary for 2.7.1.158 extracted from
- Asp1, a conserved 1/3 inositol polyphosphate kinase, regulates the dimorphic switch in Schizosaccharomyces pombe (2010), Mol. Cell. Biol., 30, 4535-4547.
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| D333A | kinase dead mutant of Asp1 | Schizosaccharomyces pombe |
| H397A | phosphatase dead mutant of Asp1 | Schizosaccharomyces pombe |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytoplasm | - |
Schizosaccharomyces pombe | 5737 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 143000 | - |
Asp1-Pk1-green fluorescent protein, gel filtration | Schizosaccharomyces pombe |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Schizosaccharomyces pombe | - |
- |
- |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ASP1 | - |
Schizosaccharomyces pombe |
| inositol polyphosphate kinase | - |
Schizosaccharomyces pombe |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | a functional Asp1 kinase domain abolishes invasive growth which is monopolar | Schizosaccharomyces pombe |
| physiological function | Asp1 kinase activity regulates cell-cell adhesion and increases resistance towards thiabendazole. The Asp1 kinase activity encoded by the N-terminal part of the protein is regulated negatively by the C-terminal domain of Asp1. Asp1 is a key regulator of the morphological switch via the cAMP protein kinase A | Schizosaccharomyces pombe |
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