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Literature summary for 2.7.1.157 extracted from
- The intrinsic reactivity of ATP and the catalytic proficiencies of kinases acting on glucose, N-acetylgalactosamine, and homoserine: a thermodynamic analysis (2009), J. Biol. Chem., 284, 22747-22757.
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | enzyme kinetics and thermodynamics, detailed overview | Homo sapiens | |
| 0.093 | - |
ATP | pH 7.0, 25°C | Homo sapiens |  |
| 0.12 | - |
N-acetyl-D-galactosamine | pH 7.0, 25°C | Homo sapiens | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | addition of Mg2+ leads to partly compensating changes in DELTAH and TDELTAS, accelerating the nonenzymatic methanolysis of ATP 11fold | Homo sapiens | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + N-acetyl-D-galactosamine | Homo sapiens | - |
ADP + N-acetyl-alpha-D-galactosamine 1-phosphate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| ATP + N-acetyl-alpha-D-galactosamine = ADP + N-acetyl-alpha-D-galactosamine 1-phosphate | ATP hydrolysis and methanolysis reaction pathways, overview | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + N-acetyl-D-galactosamine | - |
Homo sapiens | ADP + N-acetyl-alpha-D-galactosamine 1-phosphate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| GalNAcK | - |
Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 25 | - |
assay at | Homo sapiens |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 2.5 | - |
ATP | pH 7.0, 25°C | Homo sapiens | |
| 2.5 | - |
N-acetyl-D-galactosamine | pH 7.0, 25°C | Homo sapiens | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7 | - |
assay at | Homo sapiens |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 4.8 | 11 | - |
Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | addition of Mg2+ leads to partly compensating changes in DELTAH and TDELTAS, accelerating the nonenzymatic methanolysis of ATP 11fold. ATP hydrolysis and methanolysis reaction pathways, overview | Homo sapiens | |
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