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Literature summary for 2.7.1.154 extracted from
- Are class II posphoinositide 3-kinases potential targets for anticancer therapies? (2006), Bull. Cancer, 93, E53-E58.
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| membrane | predominantly localised to intracellular membranes | Homo sapiens | 16020 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Homo sapiens | PI3KC2alpha functions in vascular smooth muscle contraction, priming of neurosecretory granule exocytosis, insulin signalling and clathrin-mediated membrane trafficking. | ? | - |
? |  |
| additional information | Homo sapiens | PI3KC2beta functions in cell migration, and PTK receptor signalling | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | O00443 | - |
- |
| Homo sapiens | O00750 | - |
- |
| Homo sapiens | O75747 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| breast | PI3KC2gamma | Homo sapiens | - |
| liver | PI3KC2gamma | Homo sapiens | - |
| additional information | widely expressed, but not ubiquitous | Homo sapiens | - |
| prostate | PI3KC2gamma | Homo sapiens | - |
| thymus | high activity of PI3KC2beta | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate | - |
Homo sapiens | ADP + 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate | - |
? | |
| ATP + phosphatidylinositol | - |
Homo sapiens | ADP + phosphatidylinositol 3-phosphate | - |
? | |
| additional information | PI3KC2alpha functions in vascular smooth muscle contraction, priming of neurosecretory granule exocytosis, insulin signalling and clathrin-mediated membrane trafficking. | Homo sapiens | ? | - |
? | |
| additional information | PI3KC2beta functions in cell migration, and PTK receptor signalling | Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| PI3KC2alpha | - |
Homo sapiens |
| PI3KC2beta | - |
Homo sapiens |
| PI3KC2gamma | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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