Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.7.1.154 extracted from

  • Arcaro, A.; Khanzada, U.K.; Vanhaesebroeck, B.; Tetley, T.D.; Waterfield, M.D.; Seckl, M.J.
    Two distinct phosphoinositide 3-kinases mediate polypeptide growth factor-stimulated PKB activation (2002), EMBO J., 21, 5097-5108.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.1.154

Cloned(Commentary)

Cloned (Comment) Organism
expression of class IA and class II isozymes in HEK293 cells alter the regulation of protein kinases in response to growth factors as part of signalling cascades, overview Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
LY294002
-
 Homo sapiens
Wortmannin
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens the isozymes activate different signalling cascades via stem cell factor SCF in overexpressing cancer cell lines, e.g. association with c-Met, IGF-IR, regulation, class II PI3K C2beta blocks both protein kinase and small lung cell carcinoma in reponse to stem cell factor, polypeptide growth factors induce the recruitment of class IA and II isozymes to phosphotyrosine-containing signalling complexes, detailed overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 8 isozymes, class IA and class II, e.g. class IA p85/p110alpha or class II PI3K C2beta
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein the enzyme is regulated by phosphorylation, involving different kinases and polypeptide growth factors, overview Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
small cell lung cancer cell different cell lines overexpress different isozymes, e.g. cell lines H-69, HC-33, H-510, H-1045, and H-209 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the isozymes activate different signalling cascades via stem cell factor SCF in overexpressing cancer cell lines, e.g. association with c-Met, IGF-IR, regulation, class II PI3K C2beta blocks both protein kinase and small lung cell carcinoma in reponse to stem cell factor, polypeptide growth factors induce the recruitment of class IA and II isozymes to phosphotyrosine-containing signalling complexes, detailed overview Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
phosphoinositide 3-kinase
-
 Homo sapiens