Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P27986 | regulatory subunit alpha | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
epithelial cell | renal proximal tubule epithelial cell | Homo sapiens | - |
kidney | renal proximal tubule epithelial cell | Homo sapiens | - |
General Information | Comment | Organism |
---|---|---|
physiological function | phosphatidylinositol 3-kinase pathway inhibition is sufficient to reduce expression of Smad anchor for receptor activation protein, i.e. SARA. Phosphatidylinositol 3-kinase-dependent depletion of SARA is apparent within 6 h and does not occur at the mRNA or promoter level but is blocked by inhibition of proteasome-mediated degradation. It is a direct effect of phosphatidylinositol 3-kinase subunit alpha action, and coimmunoprecipitation of SARA and subunit alpha confirm that these proteins interact. Expression of GTPase-deficient Rab5 leads to endosomal enlargement and reduced SARA protein expression, similar to that seen with phosphatidylinositol 3-kinase inhibition | Homo sapiens |