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Literature summary for 2.7.1.153 extracted from

  • Chen, B.C.; Kang, J.C.; Lu, Y.T.; Hsu, M.J.; Liao, C.C.; Chiu, W.T.; Yeh, F.L.; Lin, C.H.
    Rac1 regulates peptidoglycan-induced nuclear factor-kappaB activation and cyclooxygenase-2 expression in RAW 264.7 macrophages by activating the phosphatidylinositol 3-kinase/Akt pathway (2009), Mol. Immunol., 46, 1179-1188.
    View publication on PubMed
Search for more literature for 2.7.1.153

Activating Compound

Activating Compound Comment Organism Structure
additional information Rac1 acts upstream of PI3K to activate downstream Akt and finally induce NF-kappaB activation and NO production, overview Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
LY294002
-
 Mus musculus
Wortmannin
-
 Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + Akt Mus musculus
-
 ADP + Akt phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
macrophage
-
 Mus musculus
-
RAW-264.7 cell
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + Akt
-
 Mus musculus ADP + Akt phosphate
-
 ?
ATP + Akt phosphorylation at Ser473 Mus musculus ADP + Akt phosphate
-
 ?

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Mus musculus

General Information

General Information Comment Organism
metabolism Rac1 regulates peptidoglycan-induced nuclear factor-kappaB activation and cyclooxygenase-2 expression in RAW 264.7 macrophages by activating the phosphatidylinositol 3-kinase/Akt pathway Mus musculus