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Literature summary for 2.7.1.153 extracted from

  • Desai, L.P.; White, S.R.; Waters, C.M.
    Cyclic mechanical stretch decreases cell migration by inhibiting phosphatidylinositol 3-kinase (PI3-kinase) and focal adhesion kinase (FAK) mediated c-Jun N-terminal kinase-1 (JNK1) activation (2009), J. Biol. Chem., 285, 4511-4519.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
additional information wounding activates PI3-kinase by 4fold Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information construction of a constitutively active PI3-kinase, CA-PI3K, mutant, whose expression stimulates translocation of Tiam1 to the membrane, increases Rac1 activity, and increases wound healing of airway epithelial cells, phenotype, overview. Expression of a dominant negative form of PI3-kinase,using an adenoviral vector, causes inhibition of airway epithelial cell wound closure, overview Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
LY294002
-
Homo sapiens
additional information cyclic stretch causes a sustained decrease in activation of PI3-kinase and inhibits wound healing Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + phosphatidylinositol-4,5-bisphosphate Homo sapiens
-
ADP + phosphatidylinositol-3,4,5-trisphosphate
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
16-HBE14o cell an airway epithelial cell line Homo sapiens
-
epithelial cell
-
Homo sapiens
-
lung
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + phosphatidylinositol-4,5-bisphosphate
-
Homo sapiens ADP + phosphatidylinositol-3,4,5-trisphosphate
-
?

Synonyms

Synonyms Comment Organism
PI3-kinase
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
Homo sapiens

General Information

General Information Comment Organism
malfunction inhibition of PI3-kinase or expression of a dominant negative form of PI3-kinase cause inhibition of airway epithelial cell wound closure Homo sapiens
physiological function PI3-kinase regulates Rac1 activity through the guanosine exchange factor Tiam1. Expression of mutant CA-PI3K causes a significant increase in membrane-associated Tiam1 Homo sapiens