Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | wounding activates PI3-kinase by 4fold | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | construction of a constitutively active PI3-kinase, CA-PI3K, mutant, whose expression stimulates translocation of Tiam1 to the membrane, increases Rac1 activity, and increases wound healing of airway epithelial cells, phenotype, overview. Expression of a dominant negative form of PI3-kinase,using an adenoviral vector, causes inhibition of airway epithelial cell wound closure, overview | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
LY294002 | - |
Homo sapiens | |
additional information | cyclic stretch causes a sustained decrease in activation of PI3-kinase and inhibits wound healing | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + phosphatidylinositol-4,5-bisphosphate | Homo sapiens | - |
ADP + phosphatidylinositol-3,4,5-trisphosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
16-HBE14o cell | an airway epithelial cell line | Homo sapiens | - |
epithelial cell | - |
Homo sapiens | - |
lung | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + phosphatidylinositol-4,5-bisphosphate | - |
Homo sapiens | ADP + phosphatidylinositol-3,4,5-trisphosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PI3-kinase | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | inhibition of PI3-kinase or expression of a dominant negative form of PI3-kinase cause inhibition of airway epithelial cell wound closure | Homo sapiens |
physiological function | PI3-kinase regulates Rac1 activity through the guanosine exchange factor Tiam1. Expression of mutant CA-PI3K causes a significant increase in membrane-associated Tiam1 | Homo sapiens |