Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | activation of phosphatidylinositol 3-kinase by membrane localization of subunit p110alpha | Mus musculus | |
additional information | activation of phosphatidylinositol 3-kinase by membrane localization of subunit p110alpha | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | generation of different transgenic lines expressing myristoylated p110A protein under the control of the epithelial-specific mouse mammary tumor virus promoter, i.e. myrp110A transgenic mice. The membrane localization of p110alpha predisposes mammary glands to neoplastic transformation, young female mutant mice show delayed mammary gland involution and morphologic changes of the mammary ducts, which is more pronounced in old animals, especially in mutiparous females, in which increased ductal branching, alveolar hyperplasia, and intraductal neoplasia are observed, phenotype, overview | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
LY294002 | a PI3K-specific inhibitor | Homo sapiens | |
LY294002 | a PI3K-specific inhibitor | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
plasma membrane | - |
Mus musculus | 5886 | - |
plasma membrane | - |
Homo sapiens | 5886 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + phosphatidylinositol-4,5-bisphosphate | Mus musculus | - |
ADP + phosphatidylinositol-3,4,5-trisphosphate | - |
? | |
ATP + phosphatidylinositol-4,5-bisphosphate | Homo sapiens | - |
ADP + phosphatidylinositol-3,4,5-trisphosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
adenosquamous carcinoma cell | - |
Mus musculus | - |
breast cancer cell | - |
Homo sapiens | - |
carcinoma cell | - |
Mus musculus | - |
mammary gland | - |
Mus musculus | - |
mammary gland | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + phosphatidylinositol-4,5-bisphosphate | - |
Mus musculus | ADP + phosphatidylinositol-3,4,5-trisphosphate | - |
? | |
ATP + phosphatidylinositol-4,5-bisphosphate | - |
Homo sapiens | ADP + phosphatidylinositol-3,4,5-trisphosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PI3K | - |
Mus musculus |
PI3K | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Mus musculus | |
ATP | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | PI3Ks constitute important regulators of various signaling pathways with relevance in cancer. Activation of PI3K by membrane localization of subunit p110alpha predisposes mammary glands to neoplastic transformation | Mus musculus |
malfunction | PI3Ks constitute important regulators of various signaling pathways with relevance in cancer. Enhanced activation of p110A, the catalytic subunit of PI3K, woccurs in a high proportion of many human tumor types. Activation of PI3K by membrane localization of subunit p110alpha predisposes mammary glands to neoplastic transformation. Perturbation of the interaction of the CDK4/Rb/E2F cascade and the PI3K signaling occurs in many human cancers | Homo sapiens |