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Literature summary for 2.7.1.153 extracted from

  • Vanhaesebroeck, B.; Leevers, S.J.; Panayotou, G.; Waterfield, M.D.
    Phosphoinositide 3-kinases: a conserved family of signal transducers (1997), Trends Biochem. Sci., 22, 267-272.
    View publication on PubMed
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mammalia the adaptor subunits of the class IA enzymes bind phosphorylated Tyr residues, thereby linking the phosphoinositide 3-kinases catalytic subunit to tyr kinase signalling pathways ?
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Organism

Organism UniProt Comment Textmining
Mammalia
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
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 Mammalia ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
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 ?
ATP + phosphatidylinositol
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 Mammalia ADP + phosphatidylinositol 3-phosphate
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 ?
ATP + phosphatidylinositol 4-phosphate
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 Mammalia ADP + phosphatidylinositol 4,5-diphosphate
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 ?
additional information enzyme interacts with active, GTP-bound Ras Mammalia ?
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 ?
additional information the adaptor subunits of the class IA enzymes bind phosphorylated Tyr residues, thereby linking the phosphoinositide 3-kinases catalytic subunit to tyr kinase signalling pathways Mammalia ?
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 ?

Subunits

Subunits Comment Organism
More
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 Mammalia