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Literature summary for 2.7.1.151 extracted from

  • Xu, R.; Paul, B.D.; Smith, D.R.; Tyagi, R.; Rao, F.; Khan, A.B.; Blech, D.J.; Vandiver, M.S.; Harraz, M.M.; Guha, P.; Ahmed, I.; Sen, N.; Gallagher, M.; Snyder, S.H.
    Inositol polyphosphate multikinase is a transcriptional coactivator required for immediate early gene induction (2013), Proc. Natl. Acad. Sci. USA, 110, 16181-16186.
    View publication on PubMedView publication on EuropePMC
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Organism

Organism UniProt Comment Textmining
Mus musculus Q7TT16
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Source Tissue

Source Tissue Comment Organism Textmining
brain
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 Mus musculus
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additional information IPMK is ubiquitously expressed Mus musculus
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neuron
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 Mus musculus
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Synonyms

Synonyms Comment Organism
inositol polyphosphate multikinase
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 Mus musculus
IPMK
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 Mus musculus

General Information

General Information Comment Organism
malfunction immediate early gene induction by electroconvulsive stimulation is virtually abolished in the brains of IPMK-deleted mice, which also display deficits in spatial memory. Dominant-negative constructs, which prevent IPMK-CBP binding, substantially decrease immediate early gene induction Mus musculus
physiological function inositol polyphosphate multikinase is a transcriptional coactivator required for immediate early gene induction. Inositol polyphosphate multikinase acts noncatalytically as a transcriptional coactivator to mediate induction of numerous immediate early genes, IEGs. Neural activity stimulates binding of IPMK to the histone acetyltransferase CBP and enhances its recruitment to IEG promoters, but IPMK regulation of CBP recruitment and IEG induction does not require its catalytic activities. The enzyme's epigenetic regulation of immediate early genes may influence diverse nonneural and neural biologic processes Mus musculus