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Literature summary for 2.7.1.151 extracted from

  • Maag, D.; Maxwell, M.J.; Hardesty, D.A.; Boucher, K.L.; Choudhari, N.; Hanno, A.G.; Ma, J.F.; Snowman, A.S.; Pietropaoli, J.W.; Xu, R.; Storm, P.B.; Saiardi, A.; Snyder, S.H.; Resnick, A.C.
    Inositol polyphosphate multikinase is a physiologic PI3-kinase that activates Akt/PKB (2011), Proc. Natl. Acad. Sci. USA, 108, 1391-1396.
    View publication on PubMedView publication on EuropePMC
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Organism

Organism UniProt Comment Textmining
Mus musculus
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Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein inhibition of p110 phosphatidylinositol 3-kinases by wortmannin prevents IPMK phosphorylation and activation Mus musculus

Source Tissue

Source Tissue Comment Organism Textmining
fibroblast embryonic fibroblast cell from mice harboring a conditionally targeted IPMK allele Mus musculus
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General Information

General Information Comment Organism
physiological function inositol polyphosphate multikinase IPMK physiologically generates phosphatidylinositol trisphosphate as well as water soluble inositol phosphates. IPMK deletion reduces growth factor-elicited Akt signaling and cell proliferation caused uniquely by loss of its phosphatidylinositol 3-kinase activity. IPMK appears to act as a molecular switch, inhibiting or stimulating Akt via its inositol phosphate kinase or inositol trisphosphate-kinase activities, respectively Mus musculus