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Literature summary for 2.7.1.151 extracted from

  • Frederick, J.P.; Mattiske, D.; Wofford, J.A.; Megosh, L.C.; Drake, L.Y.; Chiou, S.T.; Hogan, B.L.; York, J.D.
    An essential role for an inositol polyphosphate multikinase, Ipk2, in mouse embryogenesis and second messenger production (2005), Proc. Natl. Acad. Sci. USA, 102, 8454-8459.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
gene ipk2 is located on chromosome 10 Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information construction of mutants by disrution of gene ipk2, the resulting enzyme-deficient Ipk2 null mice die around embryonic day 9.5 with multiple morphological defects, including abnormal folding of the neural tube, overview Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus the enzyme plays an essential role in mouse embryogenesis and second messenger production ?
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus
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-
-

Source Tissue

Source Tissue Comment Organism Textmining
blastocyst
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Mus musculus
-
embryo
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Mus musculus
-
embryo derived from wild-type and mutant zygotes Mus musculus
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additional information enzyme expression pattern in embryos Mus musculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme plays an essential role in mouse embryogenesis and second messenger production Mus musculus ?
-
?
additional information the enzyme exhibits 3-,5-, and 6-kinase activity on inositol tris- and tetrakisphosphate substrates, e.g. 1D-myo-inositol 1,4,5-trisphosphate Mus musculus ?
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?

Synonyms

Synonyms Comment Organism
inositol polyphosphate kinase
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Mus musculus
inositol polyphosphate multikinase
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Mus musculus
IPK
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Mus musculus
Ipk2
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Mus musculus