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Literature summary for 2.7.1.150 extracted from

  • Liu, Y.; Lai, Y.C.; Hill, E.V.; Tyteca, D.; Carpentier, S.; Ingvaldsen, A.; Vertommen, D.; Lantier, L.; Foretz, M.; Dequiedt, F.; Courtoy, P.J.; Erneux, C.; Viollet, B.; Shepherd, P.R.; Tavare, J.M.; Jensen, J.; Rider, M.H.
    Phosphatidylinositol 3-phosphate 5-kinase (PIKfyve) is an AMPK target participating in contraction-stimulated glucose uptake in skeletal muscle (2013), Biochem. J., 455, 195-206.
    View publication on PubMed
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Inhibitors

Inhibitors Comment Organism Structure
YM201636 a selective PIKfyve inhibitor Didelphis sp.
YM201636 a selective PIKfyve inhibitor Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Didelphis sp. 16020
-
membrane
-
 Rattus norvegicus 16020
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Didelphis sp.
Mg2+ required Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + 1-phosphatidyl-1D-myo-inositol 3-phosphate Didelphis sp.
-
 ADP + 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate
-
 ?
ATP + 1-phosphatidyl-1D-myo-inositol 3-phosphate Rattus norvegicus
-
 ADP + 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Didelphis sp.
-
 gene PIKfyve
-
Rattus norvegicus D3ZYT8 gene PIKfyve
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein AMP-activated protein kinase stimulates the enzyme by phosphorylation at Ser307 both in vitro and in intact cells Didelphis sp.
phosphoprotein AMP-activated protein kinase stimulates the enzyme by phosphorylation at Ser307 both in vitro and in intact cells Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
C2C12 cell
-
 Rattus norvegicus
-
epitrochlearis muscle the enzyme is increased in contracting versus resting muscles Rattus norvegicus
-
kidney
-
 Didelphis sp.
-
myotube
-
 Rattus norvegicus
-
skeletal muscle
-
 Didelphis sp.
-
skeletal muscle
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 1-phosphatidyl-1D-myo-inositol 3-phosphate
-
 Didelphis sp. ADP + 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate
-
 ?
ATP + 1-phosphatidyl-1D-myo-inositol 3-phosphate
-
 Rattus norvegicus ADP + 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate
-
 ?

Synonyms

Synonyms Comment Organism
FYVE domain-containing phosphatidylinositol 3-phosphate 5-kinase
-
 Didelphis sp.
FYVE domain-containing phosphatidylinositol 3-phosphate 5-kinase
-
 Rattus norvegicus
phosphatidylinositol 3-phosphate 5-kinase
-
 Didelphis sp.
phosphatidylinositol 3-phosphate 5-kinase
-
 Rattus norvegicus
PIKfyve
-
 Didelphis sp.
PIKfyve
-
 Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Didelphis sp.
ATP
-
 Rattus norvegicus

General Information

General Information Comment Organism
malfunction enzyme inhibition reduces contraction- and AICAriboside (5-amino-4-imidazolecarboxamide riboside)-stimulated glucose uptake. PIKfyve knockdown in C2C12 myotubes reduced AICAriboside-stimulated glucose transport Rattus norvegicus
physiological function the enzyme activity is implicated in be involved in contraction/AMPK (AMP-activated protein kinase)-stimulated glucose uptake in skeletal muscle rather than insulin-stimulated glucose uptake. The enzyme is an AMPK substrate whose phosphorylation at Ser307 promotes PIKfyve translocation to endosomes for PtdIns(3,5)P2 synthesis to facilitate GLUT4 (glucose transporter 4) translocation Rattus norvegicus
physiological function the enzyme activity is required for the stimulation of skeletal muscle glucose uptake by contraction/AMPK activation. In opossum kidney cells, wild-type, but not S307A mutant, PIKfyve is recruited to endosomal vesicles in response to AMPK activation Didelphis sp.