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Literature summary for 2.7.1.150 extracted from

  • Dove, S.K.; McEwen, R.K.; Mayes, A.; Hughes, D.C.; Beggs, J.D.; Michell, R.H.
    Vac14 controls PtdIns(3,5)P2 synthesis and Fab1-dependent protein trafficking to the multivesicular body (2002), Curr. Biol., 12, 885-893.
    View publication on PubMed
Search for more literature for 2.7.1.150

Activating Compound

Activating Compound Comment Organism Structure
additional information enzyme synthesis is stimulated by a hyperosmotic shock Saccharomyces cerevisiae
additional information enzyme synthesis is stimulated by a hyperosmotic shock Schizosaccharomyces pombe

Protein Variants

Protein Variants Comment Organism
additional information enzyme defect leads to enlarged vacuoles that do not acidify correctly, the defect can be complemented by enzyme overexpression, mutants grow poorly at elevated temperature Saccharomyces cerevisiae
additional information enzyme defect leads to enlarged vacuoles that do not acidify correctly, the defect can be complemented by enzyme overexpression, mutants grow poorly at elevated temperature Schizosaccharomyces pombe

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + 1-phosphatidyl-1D-myo-inositol 3-phosphate Saccharomyces cerevisiae reaction is essential for retrograde trafficking between the vacuole/lysosome and the late endosome and also for trafficking of some proteins into the vacuole via multivesicular bodies, enzyme synthesis is regulated by vac14 and vac7, 2 upstream activators, physiological roles of the enzyme and regulation mechnaism, overview ADP + 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate
-
 ?
ATP + 1-phosphatidyl-1D-myo-inositol 3-phosphate Schizosaccharomyces pombe reaction is essential for retrograde trafficking between the vacuole/lysosome and the late endosome and also for trafficking of some proteins into the vacuole via multivesicular bodies, enzyme synthesis is regulated by vac14 and vac7, 2 upstream activators, physiological roles of the enzyme and regulation mechnaism, overview ADP + 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
-
-
Schizosaccharomyces pombe
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 1-phosphatidyl-1D-myo-inositol 3-phosphate
-
 Saccharomyces cerevisiae ADP + 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate
-
 ?
ATP + 1-phosphatidyl-1D-myo-inositol 3-phosphate
-
 Schizosaccharomyces pombe ADP + 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate
-
 ?
ATP + 1-phosphatidyl-1D-myo-inositol 3-phosphate reaction is essential for retrograde trafficking between the vacuole/lysosome and the late endosome and also for trafficking of some proteins into the vacuole via multivesicular bodies, enzyme synthesis is regulated by vac14 and vac7, 2 upstream activators, physiological roles of the enzyme and regulation mechnaism, overview Saccharomyces cerevisiae ADP + 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate
-
 ?
ATP + 1-phosphatidyl-1D-myo-inositol 3-phosphate reaction is essential for retrograde trafficking between the vacuole/lysosome and the late endosome and also for trafficking of some proteins into the vacuole via multivesicular bodies, enzyme synthesis is regulated by vac14 and vac7, 2 upstream activators, physiological roles of the enzyme and regulation mechnaism, overview Schizosaccharomyces pombe ADP + 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate
-
 ?

Synonyms

Synonyms Comment Organism
Fab1
-
 Saccharomyces cerevisiae
Fab1
-
 Schizosaccharomyces pombe
PtdIns3P 5-kinase
-
 Saccharomyces cerevisiae
PtdIns3P 5-kinase
-
 Schizosaccharomyces pombe