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Literature summary for 2.7.1.145 extracted from

  • Knecht, W.; Rozpedowska, E.; Le Breton, C.; Willer, M.; Gojkovic, Z.; Sandrini, M.P.; Joergensen, T.; Hasholt, L.; Munch-Petersen, B.; Piskur, J.
    Drosophila deoxyribonucleoside kinase mutants with enhanced ability to phosphorylate purine analogs (2007), Gene Ther., 14, 1278-1286.
    View publication on PubMed
Search for more literature for 2.7.1.145

Application

Application Comment Organism
medicine transduced deoxyribonucleoside kinases can be used to kill recipient cells in combination with nucleoside prodrugs Drosophila melanogaster

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Drosophila melanogaster

Protein Variants

Protein Variants Comment Organism
additional information creation of mutants with increased specificity for several nucleoside analogs. The mutants have a reduced ability to phosphorylate pyrimidines, while the ability to phosphorylate purine analogs is relatively similar to the wild-type enzyme Drosophila melanogaster
N45D/N64D enhanced cytotoxicity for parimidine analogs especially azidothymidine Drosophila melanogaster

Organism

Organism UniProt Comment Textmining
Drosophila melanogaster
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Drosophila melanogaster

Synonyms

Synonyms Comment Organism
Dm-dNK
-
 Drosophila melanogaster