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Literature summary for 2.7.1.138 extracted from

  • Pastukhov, O.; Schwalm, S.; Roemer, I.; Zangemeister-Wittke, U.; Pfeilschifter, J.; Huwiler, A.
    Ceramide kinase contributes to proliferation but not to prostaglandin E2 formation in renal mesangial cells and fibroblasts (2014), Cell. Physiol. Biochem., 34, 119-133.
    View publication on PubMed
Search for more literature for 2.7.1.138

Application

Application Comment Organism
medicine CerK inhibition has potential for treating mesangioproliferative kidney diseases in humans Mus musculus
medicine CerK inhibition has potential for treating mesangioproliferative kidney diseases in humans Rattus norvegicus

Protein Variants

Protein Variants Comment Organism
additional information construction of CerK knockout cells Mus musculus
additional information construction of CerK knockout cells Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
NVP-231 inhibits enzyme catalysis Mus musculus
NVP-231 inhibits enzyme catalysis Rattus norvegicus

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Mus musculus
Mg2+ required Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + ceramide Mus musculus
-
 ADP + ceramide 1-phosphate
-
 ?
ATP + ceramide Rattus norvegicus
-
 ADP + ceramide 1-phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus Q8K4Q7 gene CERK
-
Rattus norvegicus D3Z9Y3 gene CERK
-

Source Tissue

Source Tissue Comment Organism Textmining
fibroblast renal Mus musculus
-
kidney
-
 Mus musculus
-
kidney
-
 Rattus norvegicus
-
mesangial cell glomerular Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + ceramide
-
 Mus musculus ADP + ceramide 1-phosphate
-
 ?
ATP + ceramide
-
 Rattus norvegicus ADP + ceramide 1-phosphate
-
 ?

Synonyms

Synonyms Comment Organism
CERK
-
 Mus musculus
CERK
-
 Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Mus musculus
ATP
-
 Rattus norvegicus

General Information

General Information Comment Organism
malfunction loss of CerK sensitized cells towards stress-induced apoptosis, loss of CerK facilitates apoptosis induced by stress factors such as staurosporine or TNFalpha combined with cycloheximide. Cell treatment with enzyme inhibitor NVP-231 decreases DNA synthesis, but not agonist-stimulated arachidonic acid release or PGE2 synthesis, overview Rattus norvegicus
malfunction loss of CerK sensitized cells towards stress-induced apoptosis, loss of CerK facilitates apoptosis induced by stress factors such as staurosporine or TNFalpha combined with cycloheximide. Cell treatment with enzyme inhibitor NVP-231 decreases DNA synthesis, but not agonist-stimulated arachidonic acid release or PGE2 synthesis. Proliferation but not arachidonic acid release or PGE2 synthesis is reduced in CERK knockout cells, overview Mus musculus
physiological function ceramide kinase catalyzes the generation of the sphingolipid ceramide-1-phosphate, which regulates various cellular functions including cell growth and death, and inflammation. Ceramide kinase contributes to proliferation but not to prostaglandin E2 formation in renal mesangial cells and fibroblasts Mus musculus
physiological function ceramide kinase catalyzes the generation of the sphingolipid ceramide-1-phosphate, which regulates various cellular functions including cell growth and death, and inflammation. Ceramide kinase contributes to proliferation but not to prostaglandin E2 formation in renal mesangial cells and fibroblasts Rattus norvegicus