Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.7.1.138 extracted from

  • Graf, C.; Klumpp, M.; Habig, M.; Rovina, P.; Billich, A.; Baumruker, T.; Oberhauser, B.; Bornancin, F.
    Targeting ceramide metabolism with a potent and specific ceramide kinase inhibitor (2008), Mol. Pharmacol., 74, 925-932.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression in baculovirus-infected Sf9, overexpression in COS1-CerK cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
adamantane-1-carboxylic acid (2-benzoylamino-benzothiazol-6-yl)amide NVP-231, a potent, specific, and reversible CerK inhibitor that competitively inhibits binding of ceramide to CerK Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ceramide + ATP Homo sapiens key enzyme for controlling ceramide levels ceramide 1-phosphate + ADP
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
neutrophil
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ceramide + ATP
-
Homo sapiens ceramide 1-phosphate + ADP
-
?
ceramide + ATP key enzyme for controlling ceramide levels Homo sapiens ceramide 1-phosphate + ADP
-
?

Synonyms

Synonyms Comment Organism
CERK
-
Homo sapiens
hCERK
-
Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000012
-
-
Homo sapiens adamantane-1-carboxylic acid (2-benzoylamino-benzothiazol-6-yl)amide