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Literature summary for 2.7.1.138 extracted from
- Ceramide kinase uses ceramide provided by ceramide transport protein: localization to organelles of eicosanoid synthesis (2007), J. Lipid Res., 48, 1293-1304.
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| endosome membrane | - |
Homo sapiens | 10008 | - |
| Golgi apparatus | - |
Homo sapiens | 5794 | - |
| membrane | - |
Homo sapiens | 16020 | - |
| mitochondrial outer membrane | - |
Homo sapiens | 5741 | - |
| mitochondrion | - |
Homo sapiens | 5739 | - |
| trans-Golgi network | - |
Homo sapiens | 5802 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | - |
Homo sapiens |  |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 62000 | - |
SDS-PAGE | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ceramide + ATP | Homo sapiens | ceramide kinase is a critical mediator of eicosanoid synthesis, and its product, ceramide 1-phosphate, is required for the production of prostaglandins in response to several inflammatory agonists, CERK requires ceramide actively transported to the trans-Golgi network via ceramide transport protein CERT | ceramide 1-phosphate + ADP | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| A-549 cell | - |
Homo sapiens | - |
| HeLa cell | - |
Homo sapiens | - |
| lung adenocarcinoma cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + ceramide | - |
Homo sapiens | ADP + ceramide 1-phosphate | - |
? | |
| ATP + D-eythro-C16:0 ceramide | - |
Homo sapiens | ADP + D-eythro-C16:0 ceramide 1-phosphate | - |
? | |
| ATP + D-eythro-C18:0 ceramide | - |
Homo sapiens | ADP + D-eythro-C18:0 ceramide 1-phosphate | - |
? | |
| ATP + D-eythro-C20:0 ceramide | - |
Homo sapiens | ADP + D-eythro-C20:0 ceramide 1-phosphate | - |
? | |
| ceramide + ATP | - |
Homo sapiens | ceramide 1-phosphate + ADP | - |
? | |
| ceramide + ATP | ceramide kinase is a critical mediator of eicosanoid synthesis, and its product, ceramide 1-phosphate, is required for the production of prostaglandins in response to several inflammatory agonists, CERK requires ceramide actively transported to the trans-Golgi network via ceramide transport protein CERT | Homo sapiens | ceramide 1-phosphate + ADP | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| CERK | - |
Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Homo sapiens | |
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Release 2023.1 (January 2023)
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