Cloned (Comment) | Organism |
---|---|
stable expression in the cytosol and plasma membrane of rat basophilic leukemia RBL-2H3 cells, overexpression of the enzyme enhances the level of degranulation | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
N-acetylsphingosine | i.e. C2-Cer, in vivo during inhibition of mast cell degranulation | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Mus musculus | 5829 | - |
plasma membrane | - |
Mus musculus | 5886 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | optimal activation at 1 mM, enzyme is a mediator of calcium-dependent degranulation in mast cells | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + ceramide | Mus musculus | - |
ADP + ceramide 1-phosphate | - |
? | |
additional information | Mus musculus | the enzyme is a mediator of calcium-dependent degranulation in mast cells | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + ceramide | - |
Mus musculus | ADP + ceramide 1-phosphate | - |
? | |
additional information | the enzyme is a mediator of calcium-dependent degranulation in mast cells | Mus musculus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
CERK | - |
Mus musculus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
30 | - |
assay at | Mus musculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Mus musculus |