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Literature summary for 2.7.1.137 extracted from

  • Axelsson, L.; Hellberg, C.; Melander, F.; Smith, D.; Zheng, L.; Andersson, T.
    Clustering of b2-Integrins on Human Neutrophils Activates Dual Signaling Pathways to PtdIns 3-Kinase (2000), Exp. Cell Res., 256, 257-263.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
additional information b2-integrins activate the tyrosine kinases p58c-fgr and p59/61hck and causes them to associate with the p85 subunit of PtdIns 3-kinase. Thus, even if PtdIns 3-kinase is not activated by p21ras, it can maintain full enzyme activity due to the interaction with p58c-fgr or p59/61hck Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 1-phosphatidylinositol
-
Homo sapiens ADP + phosphatidylinositol 3-phosphate
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