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Literature summary for 2.7.1.136 extracted from

  • Taniguchi, K.; Nakamura, A.; Tsurubuchi, K.; Ishii, A.; O'Hara, K.; Sawai, T.
    Appearance in Japan of highly macrolide-resistant Escherichia coli producing macrolide 2'-phosphotransferase II (1999), Microbios, 97, 137-144.
    View publication on PubMed
Search for more literature for 2.7.1.136

Cloned(Commentary)

Cloned (Comment) Organism
mph gene for Escherichia coli strain CU1 is identical to that previously reported for mphB from Escherichia coli strain BM 2506 Escherichia coli

Localization

Localization Comment Organism GeneOntology No. Textmining
additional information mph gene is located on nontransmissible plasmid DNA for Escherichia coli strain CU1 Escherichia coli
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Organism

Organism UniProt Comment Textmining
Escherichia coli
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 macrolide 2'-phosphotransferase type II, similar levels of activity with 14-member ring macrolides or 16-member ring macrolides, strain CU1 or BM 2506
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + clarithromycin 46-55% activity with respect to oleandomycin for strain CU1, 17% activity with respect to oleandomycin for strain BM 2506 Escherichia coli ?
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 ?
ATP + erythromycin 81% activity with respect to oleandomycin for strain CU1, 24% activity with respect to oleandomycin for strain BM 2506 Escherichia coli ADP + erythromycin-2'-O-phosphate
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 ?
ATP + josamycin 75-95% activity with respect to oleandomycin for strain CU1, 96% activity with respect to oleandomycin for strain BM 2506 Escherichia coli ?
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 ?
ATP + kitasamycin 52% activity with respect to oleandomycin for strain CU1, 61% activity with respect to oleandomycin for strain BM 2506 Escherichia coli ?
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 ?
ATP + oleandomycin
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 Escherichia coli ADP + oleandomycin 2'-O-phosphate
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 ?
ATP + roxithromycin 42% activity with respect to oleandomycin for strain CU1, about 2% activity with respect to oleandomycin for strain BM 2506 Escherichia coli ?
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 ?
ATP + spiramycin 57-75% activity with respect to oleandomycin for strain CU1, 26% activity with respect to oleandomycin for strain BM 2506 Escherichia coli ADP + spiramycin 2'-O-phosphate
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 ?
ATP + troleandomycin 82% activity with respect to oleandomycin for strain CU1, 105% activity with respect to oleandomycin for strain BM 2506 Escherichia coli ?
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 ?
ATP + tylosin 60% activity with respect to oleandomycin for strain CU1, 4% activity with respect to oleandomycin for strain BM 2506 Escherichia coli ADP + tylosin 2'-phosphate
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 ?