Protein Variants | Comment | Organism |
---|---|---|
additional information | construction of Itpkb-/- mice transgenically expressing Itpkb in thymocytes, tese mutant mice have some peripheral T cells left. The mutant mice shows partial rescue of T cell lineage development through recombinant expression of HA-tagged isozyme Itpkb in thymocytes | Mus musculus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | the enzyme is highly activated by Ca2+/calmodulin | Mus musculus | |
Mg2+ | required | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 1D-myo-inositol 1,4,5-trisphosphate | Mus musculus | - |
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | B2RXC2 | gene Itpkb | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
B-lymphocyte | - |
Mus musculus | - |
mast cell | - |
Mus musculus | - |
additional information | ubiquitous tissue expression of isozyme Itpkb, the Itpkb protein contributes mainly to the majority of the Ins(1,4,5)P3 3-kinase activity in resting T and B lymphocytes as well as in neutrophils and mast cells | Mus musculus | - |
neutrophil | - |
Mus musculus | - |
spleen | - |
Mus musculus | - |
T-cell | - |
Mus musculus | - |
T-lymphocyte | - |
Mus musculus | - |
thymocyte | - |
Mus musculus | - |
thymus | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 1D-myo-inositol 1,4,5-trisphosphate | - |
Mus musculus | ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
inositol 1,4,5-trisphosphate 3-kinase B | - |
Mus musculus |
Itpkb | - |
Mus musculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
malfunction | mice genetically-deficient for the B isoform of the inositol 1,4,5-trisphosphate 3-kinase have a severe defect in thymocytes differentiation and thus lack peripheral T cells. Mutant T cells show an increased activated/memory phenotype as well as a decreased proliferative capacity and survival, Itpkb-deficient peripheral T cells have also an increased capacity to secrete cytokines upon stimulation | Mus musculus |
physiological function | functional role of isozyme Itpkb in peripheral T cells, potential role for Itpkb in autoimmunity | Mus musculus |