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Literature summary for 2.7.1.127 extracted from

  • Kwon, Y.U.; Im, J.; Choi, G.; Kim, Y.S.; Choi, K.Y.; Chung, S.K.
    Synthesis of three enantiomeric pairs of scyllo-inositol phosphate and molecular interactions between all possible regioisomers of scyllo-inositol phosphate and inositol 1,4,5-trisphosphate 3-kinase (2003), Bioorg. Med. Chem. Lett., 13, 2981-2984.
    View publication on PubMed
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Inhibitors

Inhibitors Comment Organism Structure
D-myo-inositol 1,4,5-trisphosphate strong inhibition, purified recombinant enzyme, IC50 value is 0.003 mM in absence of Ca2+ Rattus norvegicus
D-scyllo-inositol 1,2,3,4-tetrakisphosphate purified recombinant enzyme, IC50 value is above 0.1 mM in absence of Ca2+ Rattus norvegicus
D-scyllo-inositol 1,2,4-trisphosphate purified recombinant enzyme, IC50 value is 0.044 mM in absence of Ca2+ Rattus norvegicus
L-scyllo-inositol 1,2,3,4-tetrakisphosphate purified recombinant enzyme, IC50 value is above 0.1 mM in absence of Ca2+ Rattus norvegicus
L-scyllo-inositol 1,2,4-trisphosphate purified recombinant enzyme, IC50 value is 0.006 mM in absence of Ca2+ Rattus norvegicus
additional information inhibitor binding structures and mechanism, scyllo-inositol pentakisphosphate, scyllo-inositol hexakisphosphate, scyllo-inositol monophosphate, and scyllo-inositol S-bisphosphates are poor inhibitors Rattus norvegicus
scyllo-inositol 1,2,3,5-tetrakisphosphate weak inhibition, purified recombinant enzyme, IC50 value is 0.028 mM in absence of Ca2+ Rattus norvegicus
scyllo-inositol 1,2,3-trisphosphate purified recombinant enzyme, IC50 value is 0.027 mM in absence of Ca2+ Rattus norvegicus
scyllo-inositol 1,2,4,5-tetrakisphosphate weak inhibition, purified recombinant enzyme, IC50 value is 0.039 mM in absence of Ca2+ Rattus norvegicus
scyllo-inositol 1,3,5-trisphosphate purified recombinant enzyme, IC50 value is 0.090 mM in absence of Ca2+ Rattus norvegicus

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ required Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 1D-myo-inositol 1,4,5-trisphosphate
-
 Rattus norvegicus ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
 ?

Synonyms

Synonyms Comment Organism
inositol 1,4,5-trisphosphate 3-kinase
-
 Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Rattus norvegicus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.003
-
 strong inhibition, purified recombinant enzyme, IC50 value is 0.003 mM in absence of Ca2+ Rattus norvegicus D-myo-inositol 1,4,5-trisphosphate
0.006
-
 purified recombinant enzyme, IC50 value is 0.006 mM in absence of Ca2+ Rattus norvegicus L-scyllo-inositol 1,2,4-trisphosphate
0.027
-
 purified recombinant enzyme, IC50 value is 0.027 mM in absence of Ca2+ Rattus norvegicus scyllo-inositol 1,2,3-trisphosphate
0.028
-
 weak inhibition, purified recombinant enzyme, IC50 value is 0.028 mM in absence of Ca2+ Rattus norvegicus scyllo-inositol 1,2,3,5-tetrakisphosphate
0.039
-
 weak inhibition, purified recombinant enzyme, IC50 value is 0.039 mM in absence of Ca2+ Rattus norvegicus scyllo-inositol 1,2,4,5-tetrakisphosphate
0.044
-
 purified recombinant enzyme, IC50 value is 0.044 mM in absence of Ca2+ Rattus norvegicus D-scyllo-inositol 1,2,4-trisphosphate
0.09
-
 purified recombinant enzyme, IC50 value is 0.090 mM in absence of Ca2+ Rattus norvegicus scyllo-inositol 1,3,5-trisphosphate
0.1
-
 purified recombinant enzyme, IC50 value is above 0.1 mM in absence of Ca2+ Rattus norvegicus D-scyllo-inositol 1,2,3,4-tetrakisphosphate
0.1
-
 purified recombinant enzyme, IC50 value is above 0.1 mM in absence of Ca2+ Rattus norvegicus L-scyllo-inositol 1,2,3,4-tetrakisphosphate