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Literature summary for 2.7.1.127 extracted from

  • Irvine, R.F.; Schell, M.J.
    Back in the water: The return of the inositol phosphates (2001), Nat. Rev. Mol. Cell Biol., 2, 327-338.
    View publication on PubMed
Search for more literature for 2.7.1.127

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ isoenzyme C is regulated by Ca2+ to a lesser extend than isoenzymes A and B Homo sapiens
Ca2+ activation by Ca2+/calmodulin Mammalia
Ca2+ activation by Ca2+/calmodulin Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + 1D-myo-inositol 1,4,5-trisphosphate Homo sapiens
-
 ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
 ?
ATP + 1D-myo-inositol 1,4,5-trisphosphate Mammalia role in rapidly metabolizing the pool of Ins(1,4,5)P3 that is generated when phospholipase C-coupled receptors are activated, the product Ins(1,3,4,5)P4 can protect Ins(1,4,5)P3 against hydrolysis and therefore increase its effectiveness, detailed consequences of Ins(1,3,4,5)P4 generation in the cell, all 3 isoenzymes are regulated by calmodulin, 2 isoenzymes are regulated by a Ca2+/calmodulin-dependent protein kinase II ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 3 isoenzymes: A, B and C
-
Mammalia
-
 at least 3 isoforms: A, B and C
-

Source Tissue

Source Tissue Comment Organism Textmining
additional information isoenzyme C is not found in brain Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 1D-myo-inositol 1,4,5-trisphosphate
-
 Mammalia ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
 ?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
-
 Homo sapiens ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
 ?
ATP + 1D-myo-inositol 1,4,5-trisphosphate role in rapidly metabolizing the pool of Ins(1,4,5)P3 that is generated when phospholipase C-coupled receptors are activated, the product Ins(1,3,4,5)P4 can protect Ins(1,4,5)P3 against hydrolysis and therefore increase its effectiveness, detailed consequences of Ins(1,3,4,5)P4 generation in the cell, all 3 isoenzymes are regulated by calmodulin, 2 isoenzymes are regulated by a Ca2+/calmodulin-dependent protein kinase II Mammalia ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
 ?

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Mammalia
ATP
-
 Homo sapiens
Calmodulin activation by Ca2+/calmodulin Mammalia
Calmodulin activation by Ca2+/calmodulin Homo sapiens