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BRENDA support

Literature summary for 2.7.1.127 extracted from

  • Morris, A.J.; Downes, C.P.; Harden, T.K.; Michell, R.H.
    Turkey erythrocytes possess a membrane-associated inositol 1,4,5-trisphosphate 3-kinase that is activated by Ca2+ in the presence of calmodulin (1987), Biochem. J., 248, 489-493.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.1.127

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Meleagris gallopavo 5829
-
membrane membrane-bound, intrinsic membrane protein, accounts for about 25% of total activity Meleagris gallopavo 16020
-
soluble predominantly Meleagris gallopavo
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ activation by Ca2+/calmodulin Meleagris gallopavo
Mg2+
-
 Meleagris gallopavo

Organism

Organism UniProt Comment Textmining
Meleagris gallopavo
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
erythrocyte
-
 Meleagris gallopavo
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 1D-myo-inositol 1,4,5-trisphosphate
-
 Meleagris gallopavo ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
 ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.2
-
 assay at Meleagris gallopavo

Cofactor

Cofactor Comment Organism Structure
ATP ATP-dependent Meleagris gallopavo
Calmodulin activation by Ca2+/calmodulin Meleagris gallopavo