Literature summary for 2.7.1.12 extracted from

Rohatgi, N.; Gudmundsson, S.; Rolfsson, O.
Kinetic analysis of gluconate phosphorylation by human gluconokinase using isothermal titration calorimetry (2015), FEBS Lett., 589, 3548-3555.

Search for more literature for 2.7.1.12

Inhibitors

Inhibitors	Comment	Organism	Structure
D-gluconate	binds to an enzyme-ADP complex forming a dead-end complex	Homo sapiens

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
additional information	-	additional information	isothermal titration calorimetry to determine kinetic and thermodynamic properties. The KM for ATP lies in the range 0.1 to 0.3 mM at varying concentrations of Glcn. The KM of D-glucuronate is in the range 0.2 to 0.3 mM, pH 7.2, 25°C	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q5T6J7	-	-

Reaction

Reaction	Comment	Organism	Reaction ID
ATP + D-gluconate = ADP + 6-phospho-D-gluconate	reaction follows a ternary complex mechanism, with ATP binding first	Homo sapiens	a

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + D-gluconate	-	Homo sapiens	ADP + 6-phospho-D-gluconate	-	?

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)