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Literature summary for 2.7.1.12 extracted from

  • Sable, H.Z.; Guarino, A.J.
    Phosphorylation of gluconate in yeast extracts (1952), J. Biol. Chem., 196, 395-402.
    View publication on PubMed
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Inhibitors

Inhibitors Comment Organism Structure
Mg2+ optimal activation at 5-7 mM, inhibition above Saccharomyces cerevisiae

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.2
-
 ATP 30°C, pH 7.6 Saccharomyces cerevisiae
1.74
-
 D-gluconate 30°C, pH 7.6 Saccharomyces cerevisiae

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ activates Saccharomyces cerevisiae
Mg2+ Km: 1.68 mM Saccharomyces cerevisiae
Mg2+ inhibition above Saccharomyces cerevisiae
Mg2+ optimum concentration: 5-7 mM Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + D-gluconate Saccharomyces cerevisiae conversion of glucose to pyruvate ADP + 6-phospho-D-gluconate
-
 ?

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
 baker's yeast and brewer's yeast
-

Purification (Commentary)

Purification (Comment) Organism
baker's yeast and brewer's yeast Saccharomyces cerevisiae

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + D-gluconate
-
 Saccharomyces cerevisiae ADP + 6-phospho-D-gluconate
-
 ?
ATP + D-gluconate conversion of glucose to pyruvate Saccharomyces cerevisiae ADP + 6-phospho-D-gluconate
-
 ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.2
-
-
 Saccharomyces cerevisiae

pH Range

pH Minimum pH Maximum Comment Organism
6 9 pH 6: about 30% of activity maximum, pH 9: about 40% of activity maximum Saccharomyces cerevisiae