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Literature summary for 2.7.1.118 extracted from

  • Falke, D.; Labenz, J.; Brauer, D.; Müller, W.E.G.
    Adenosine diphosphate: thymidine 5-phosphotransferase, a new enzyme activity, associated with the Herpes simplex virus-induced deoxypyrimidine kinase (1982), Biochim. Biophys. Acta, 708, 99-103.
    View publication on PubMed
Search for more literature for 2.7.1.118

Inhibitors

Inhibitors Comment Organism Structure
EDTA
-
 Herpes simplex virus
N-ethylmaleimide
-
 Herpes simplex virus
p-chloromercuribenzoate
-
 Herpes simplex virus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0005
-
 thymidine Herpes simplex virus type 2 Herpes simplex virus
0.0008
-
 thymidine Herpes simplex virus type 1 Herpes simplex virus
0.012
-
 ADP Herpes simplex virus type 1 Herpes simplex virus
0.019
-
 ADP Herpes simplex virus type 2 Herpes simplex virus

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ 10% residual activity in absence of Mg2+ Herpes simplex virus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ADP + thymidine Herpes simplex virus
-
 AMP + dTMP
-
 ?

Organism

Organism UniProt Comment Textmining
Herpes simplex virus
-
 type 1 or type 2, induced in mouse fibroblasts
-

Source Tissue

Source Tissue Comment Organism Textmining

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.0048
-
-
 Herpes simplex virus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ADP + thymidine
-
 Herpes simplex virus AMP + dTMP
-
 ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.5 7.5 Herpes simplex virus type 1 Herpes simplex virus