Literature summary for 2.7.1.113 extracted from

Johansson, K.; Ramaswamy, S.; Ljungcrantz, C.; Knecht, W.; Piskur, J.; Munch-Petersen, B.; Eriksson, S.; Eklund, H.
Structural basis for substrate specificities of cellular deoxyribonucleoside kinases (2001), Nat. Struct. Biol., 8, 616-620.

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Application

Application	Comment	Organism
medicine	the enzyme activates a number of medically important nucleoside analogues	Homo sapiens

Crystallization (Commentary)

Crystallization (Comment)	Organism
purified recombinant enzyme, hanging drop vapour diffusion method, enzyme solution containing 7 mg/ml protein, 5 mM MgCl2, and 5 mM ATP, mixed with an equal volume of cyrstallization solution containing 0.1 M Na-citrate, pH 6.5, 0.2 M ammonium acetate, and 30% w/v PEG 4000, X-ray diffraction structure determination and analysis at 2.8 A resolution, molecular replacement method	Homo sapiens

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Mg2+	-	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q16854	-	-

Reaction

Reaction	Comment	Organism	Reaction ID
ATP + deoxyguanosine = ADP + dGMP	substrate interactions and binding mechanism, and active site structure	Homo sapiens	a

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + 2'-deoxyguanosine	-	Homo sapiens	ADP + 2'-deoxyguanosine 5'-phosphate	-	?
additional information	the enzyme is highly specific for purine substrates, Arg118 is responsible for the substrate specificity	Homo sapiens	?	-	?

Synonyms

Synonyms	Comment	Organism
DGK	-	Homo sapiens

Cofactor

Cofactor	Comment	Organism	Structure
ATP	-	Homo sapiens

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Release 2023.1 (January 2023)