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Literature summary for 2.7.1.113 extracted from

  • Eriksson, S.; Munch-Petersen, B.; Johansson, K.; Eklund, H.
    Structure and function of cellular deoxyribonucleoside kinases (2002), Cell. Mol. Life Sci., 59, 1327-1346.
    View publication on PubMed
Search for more literature for 2.7.1.113

Activating Compound

Activating Compound Comment Organism Structure
Triton X-100
-
 Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
gene is localized on chromosome 2q13 Homo sapiens

Crystallization (Commentary)

Crystallization (Comment) Organism
enzyme in complex with ATP Homo sapiens

General Stability

General Stability Organism
Triton X-100 and ATP stabilize Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
dATP feedback inhibition Homo sapiens
dGTP feedback inhibition Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrial matrix
-
 Homo sapiens 5759
-
mitochondrion enzyme possesses an N-terminal mitochondrial import signal Homo sapiens 5739
-
additional information the enzyme leaks out into the cytosol during cell apoptosis Homo sapiens
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
 Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
30000
-
 2 * 30000 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + 2'-deoxyadenosine Homo sapiens
-
 ADP + 2'-deoxyadenosine 5'-phosphate
-
 ?
ATP + 2'-deoxyguanosine Homo sapiens
-
 ADP + 2'-deoxyguanosine 5'-phosphate
-
 ?
UTP + 2'-deoxyadenosine Homo sapiens
-
 UDP + 2'-deoxyadenosine 5'-phosphate
-
 ?
UTP + 2'-deoxyguanosine Homo sapiens
-
 UDP + 2'-deoxyguanosine 5'-phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q16854 constitutive expression
-

Purification (Commentary)

Purification (Comment) Organism
enzyme activity is stabilized during purification in presence of Triton X-100 and ATP Homo sapiens

Reaction

Reaction Comment Organism Reaction ID
ATP + deoxyguanosine = ADP + dGMP substrate interactions, reaction mechanism Homo sapiens
a

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Homo sapiens
-
liver
-
 Homo sapiens
-
lymphoid tissue
-
 Homo sapiens
-
skin
-
 Homo sapiens
-
spleen
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 1-beta-D-arabinofuranosyladenine
-
 Homo sapiens ADP + 1-beta-D-arabinofuranosyladenine 5'-phosphate
-
 ?
ATP + 2',2'-difluorodeoxyguanosine
-
 Homo sapiens ADP + 2',2'-difluorodeoxyguanosine 5'-phosphate
-
 ?
ATP + 2'-deoxyadenosine
-
 Homo sapiens ADP + 2'-deoxyadenosine 5'-phosphate
-
 ?
ATP + 2'-deoxyguanosine
-
 Homo sapiens ADP + 2'-deoxyguanosine 5'-phosphate
-
 ?
ATP + 2'-deoxyinosine
-
 Homo sapiens ADP + 2'-deoxyinosine 5'-phosphate
-
 ?
ATP + 2-chloro-2'-arabinofluoro-2'-deoxyadenosine
-
 Homo sapiens ADP + 2-chloro-2'-arabinofluoro-2'-deoxyadenosine 5'-phosphate
-
 ?
ATP + 2-chlorodeoxyadenosine
-
 Homo sapiens ADP + 2-chlorodeoxyadenosine 5'-phosphate
-
 ?
ATP + 9-beta-D-arabinofuranosylguanine
-
 Homo sapiens ADP + 9-beta-D-arabinofuranosylguanine 5'-phosphate
-
 ?
ATP + ganciclovir i.e. 9-(1,3-dihydroxy-2-propoxymethyl)-guanine, low activity Homo sapiens ADP + ganciclovir phosphate
-
 ?
ATP + penciclovir i.e. 9-(2-hydroxy-1-hydroxymethyl-ethoxymethyl)-guanine, low activity Homo sapiens ADP + penciclovir 5'-phosphate
-
 ?
additional information substrate interactions, overview, enzyme shows relaxed enantioselectivity, accepting D- and L-enantiomers of beta-deoxyguanosine but with lower activity than alpha-L-deoxyguanosine, and beta-L-deoxyadenosine, enzyme accepts purine deoxynucleosides and analogues as substrates utilizing a triphosphate donor substrate Homo sapiens ?
-
 ?
UTP + 2'-deoxyadenosine
-
 Homo sapiens UDP + 2'-deoxyadenosine 5'-phosphate
-
 ?
UTP + 2'-deoxyguanosine
-
 Homo sapiens UDP + 2'-deoxyguanosine 5'-phosphate
-
 ?
UTP + 2'-deoxyinosine
-
 Homo sapiens UDP + 2'-deoxyinosine 5'-phosphate
-
 ?

Subunits

Subunits Comment Organism
dimer 2 * 30000 Homo sapiens
More ternary and quarternary structure analysis, overview Homo sapiens

Synonyms

Synonyms Comment Organism
DGK
-
 Homo sapiens
nucleoside triphosphate: deoxyguanosine 5'-phosphotransferase
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP binding site structure and interactions, Gln111, Arg118, Met99, and Asp147 are involved, overview Homo sapiens
additional information enzyme accepts several triphosphate donor substrates with preference for ATP and UTP Homo sapiens
UTP
-
 Homo sapiens