General Stability | Organism |
---|---|
ATP stabilizes the enzyme | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
diphosphate | competitive inhibition | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | the reaction with triphosphate follows strict Michaelis-Menten kinetics, while ATP exhibits negative cooperativity | Homo sapiens | |
0.02 | - |
ATP | pH 7.5, 37°C | Homo sapiens | |
0.092 | - |
Triphosphate | pH 7.5, 37°C | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 2'-deoxyguanosine | Homo sapiens | - |
ADP + 2'-deoxyguanosine 5'-phosphate | - |
ir |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.007 | - |
purified recombinant enzyme, substrates deoxyguanosine and ATP | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 2'-deoxyguanosine | - |
Homo sapiens | ADP + 2'-deoxyguanosine 5'-phosphate | - |
ir | |
additional information | no activity with diphosphate as phosphate donor | Homo sapiens | ? | - |
? | |
triphosphate + 2'-deoxyguanosine | triphosphate is active with 2'deoxyguanosine, 50% of the activity with ATP | Homo sapiens | diphosphate + 2'-deoxyguanosine 5'-phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
DGK | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
assay at | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | preferred phosphate donor substrate, stabilizes the enzyme | Homo sapiens | |
additional information | no activity with diphosphate as phosphate donor | Homo sapiens |