Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.7.1.113 extracted from

  • Herrstrom Sjoberg, A.; Wang, L.; Eriksson, S.
    Antiviral guanosine analogs as substrates for deoxyguanosine kinase: implications for chemotherapy (2001), Antimicrob. Agents Chemother., 45, 739-742.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
-
Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
dAMP
-
Homo sapiens
dATP
-
Homo sapiens
dGMP
-
Homo sapiens
dGTP
-
Homo sapiens
dIMP
-
Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0028
-
deoxyguanosine pH 7.6, 37°C, recombinant deoxguanosine kinase, cosubstrate ATP Homo sapiens
0.0037
-
deoxyguanosine pH 7.6, 37°C, recombinant deoxguanosine kinase, cosubstrate UTP Homo sapiens
0.008
-
2-chlorodeoxyadenosine pH 7.6, 37°C, recombinant deoxguanosine kinase, cosubstrate UTP Homo sapiens
0.062
-
2-chlorodeoxyadenosine pH 7.6, 37°C, recombinant deoxguanosine kinase, cosubstrate ATP Homo sapiens

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Bos taurus
-
heart
-
Bos taurus
-
liver
-
Bos taurus
-
thymus
-
Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 2',3'-dideoxyguanosine recombinant deoxyguanosine kinase, 14% of activity with deoxyguanosine Homo sapiens ADP + 2',3'-dideoxyguanosine 5'-monophosphate
-
?
ATP + 2-chloro-2'-deoxyadenosine
-
Homo sapiens ADP + 2-chloro-2'-deoxyadenosine monophosphate
-
?
ATP + 3'-fluoro-2',3'-dideoxyguanosine recombinant deoxyguanosine kinase, 14% of activity with deoxyguanosine Homo sapiens ADP + 3'-fluoro-2',3'-dideoxyguanosine 5'-monophosphate
-
?
ATP + 9-(1,3-dihydroxy-2-propoxymethyl)guanine antiherpesvirus drug ganciclovir, recombinant mitochondrial deoxyguanosine kinase, 6% of activity with deoxyguanosine Homo sapiens ADP + 9-(1,3-dihydroxy-2-propoxymethyl)guanine 5'-monophosphate
-
?
ATP + 9-(4-hydroxy-3-hydroxymethylbutyl-1-yl)guanine antiherpesvirus drug penciclovir, recombinant mitochondrial deoxyguanosine kinase, 50% of activity with deoxyguanosine Homo sapiens ADP + 9-(4-hydroxy-3-hydroxymethylbutyl-1-yl)guanine 5'-monophosphate
-
?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0004
-
dGTP pH 7.6, 37°C, recombinant deoxyguanosine kinase Homo sapiens
0.004
-
dGMP pH 7.6, 37°C, recombinant deoxyguanosine kinase Homo sapiens
0.028
-
dAMP pH 7.6, 37°C, recombinant deoxyguanosine kinase Homo sapiens
0.041
-
dATP pH 7.6, 37°C, recombinant deoxyguanosine kinase Homo sapiens
0.078
-
dIMP pH 7.6, 37°C, recombinant deoxyguanosine kinase Homo sapiens