Cloned (Comment) | Organism |
---|---|
- |
Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
dAMP | - |
Homo sapiens | |
dATP | - |
Homo sapiens | |
dGMP | - |
Homo sapiens | |
dGTP | - |
Homo sapiens | |
dIMP | - |
Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0028 | - |
deoxyguanosine | pH 7.6, 37°C, recombinant deoxguanosine kinase, cosubstrate ATP | Homo sapiens | |
0.0037 | - |
deoxyguanosine | pH 7.6, 37°C, recombinant deoxguanosine kinase, cosubstrate UTP | Homo sapiens | |
0.008 | - |
2-chlorodeoxyadenosine | pH 7.6, 37°C, recombinant deoxguanosine kinase, cosubstrate UTP | Homo sapiens | |
0.062 | - |
2-chlorodeoxyadenosine | pH 7.6, 37°C, recombinant deoxguanosine kinase, cosubstrate ATP | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
- |
- |
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Bos taurus | - |
heart | - |
Bos taurus | - |
liver | - |
Bos taurus | - |
thymus | - |
Bos taurus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 2',3'-dideoxyguanosine | recombinant deoxyguanosine kinase, 14% of activity with deoxyguanosine | Homo sapiens | ADP + 2',3'-dideoxyguanosine 5'-monophosphate | - |
? | |
ATP + 2-chloro-2'-deoxyadenosine | - |
Homo sapiens | ADP + 2-chloro-2'-deoxyadenosine monophosphate | - |
? | |
ATP + 3'-fluoro-2',3'-dideoxyguanosine | recombinant deoxyguanosine kinase, 14% of activity with deoxyguanosine | Homo sapiens | ADP + 3'-fluoro-2',3'-dideoxyguanosine 5'-monophosphate | - |
? | |
ATP + 9-(1,3-dihydroxy-2-propoxymethyl)guanine | antiherpesvirus drug ganciclovir, recombinant mitochondrial deoxyguanosine kinase, 6% of activity with deoxyguanosine | Homo sapiens | ADP + 9-(1,3-dihydroxy-2-propoxymethyl)guanine 5'-monophosphate | - |
? | |
ATP + 9-(4-hydroxy-3-hydroxymethylbutyl-1-yl)guanine | antiherpesvirus drug penciclovir, recombinant mitochondrial deoxyguanosine kinase, 50% of activity with deoxyguanosine | Homo sapiens | ADP + 9-(4-hydroxy-3-hydroxymethylbutyl-1-yl)guanine 5'-monophosphate | - |
? |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0004 | - |
dGTP | pH 7.6, 37°C, recombinant deoxyguanosine kinase | Homo sapiens | |
0.004 | - |
dGMP | pH 7.6, 37°C, recombinant deoxyguanosine kinase | Homo sapiens | |
0.028 | - |
dAMP | pH 7.6, 37°C, recombinant deoxyguanosine kinase | Homo sapiens | |
0.041 | - |
dATP | pH 7.6, 37°C, recombinant deoxyguanosine kinase | Homo sapiens | |
0.078 | - |
dIMP | pH 7.6, 37°C, recombinant deoxyguanosine kinase | Homo sapiens |