Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Arachidonoyl-CoA | - |
Oryctolagus cuniculus | |
linoleoyl-CoA | - |
Oryctolagus cuniculus | |
additional information | acetyl-CoA, malonyl-CoA, palmitoylcarnitine, and palmitic acid in the presence of CoASH are without effect on enzyme activity | Oryctolagus cuniculus | |
oleoyl-CoA | - |
Oryctolagus cuniculus | |
palmitoyl-CoA | low micromolar inhibitor, MgAMP and MgADP but not MgATP protect the enzyme against inhibition by palmitoyl-CoA. Acyl-protein thioesterase-1 reverses palmitoyl-CoA-mediated enzyme inhibition | Oryctolagus cuniculus | |
palmitoylcarnitine-CoA | - |
Oryctolagus cuniculus | |
S-hexadecyl-CoA | - |
Oryctolagus cuniculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Oryctolagus cuniculus | 5829 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Oryctolagus cuniculus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
ammonium sulfate precipitation DEAE-Sephacel gel filtration and Bio-Gel filtration | Oryctolagus cuniculus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
muscle | - |
Oryctolagus cuniculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + D-fructose 6-phosphate | - |
Oryctolagus cuniculus | ADP + D-fructose 1,6-bisphosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
6-phosphofructo 1-kinase | - |
Oryctolagus cuniculus |
PFK-1 | - |
Oryctolagus cuniculus |
phosphofructokinase-1 | - |
Oryctolagus cuniculus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0015 | - |
in 50 mM imidazole, pH 8.0, containing 50 mM KCl and 2 mM MgCl2, at 22°C | Oryctolagus cuniculus | palmitoyl-CoA |
General Information | Comment | Organism |
---|---|---|
physiological function | the enzyme catalyzes the first committed and rate-determining step of glycolysis and thus represents an essential metabolic control point or node for carbohydrate utilization | Oryctolagus cuniculus |