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Literature summary for 2.7.1.11 extracted from

  • Durante, P.; Raleigh, X.; Gomez, M.E.; Campos, G.; Ryder, E.
    Isozyme analysis of human normal polymorphonuclear leukocyte phosphofructokinase (1995), Biochem. Biophys. Res. Commun., 216, 898-905.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
D-Glucose 1,6-bisphosphate 0.02 mM, 474% and 360% activation of M- and L-type PFK, respectively Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
ATP inhibition of M-type PFK above 0.1 mM Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.047
-
D-fructose 6-phosphate pH 7.1, 25°C, M-type PFK Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
74250
-
x * 74250, L-type PFK Homo sapiens
79500
-
x * 79500, M-type PFK Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
QAE-Sepharose, partially purified Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
leukocyte polymorphonuclear leukocytes, predominance of L-type PFK Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + D-fructose 6-phosphate
-
Homo sapiens ADP + D-fructose 1,6-bisphosphate
-
?

Subunits

Subunits Comment Organism
? x * 74250, L-type PFK Homo sapiens
? x + 82000, C-type PFK Homo sapiens
? x * 79500, M-type PFK Homo sapiens