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Literature summary for 2.7.1.11 extracted from

  • Habison, A.; Kubicek, C.P.; Röhr, M.
    Partial purification and regulatory properties of phosphofructokinase from Aspergillus niger (1983), Biochem. J., 209, 669-676.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
ADP activation Aspergillus niger
ADP at high fructose 6-phosphate concentration, inhibits at low fructose 6-phosphate concentration Aspergillus niger
AMP activation at low fructose 6-phosphate concentrations, inhibition at high fructose 6-phosphate concentrations Aspergillus niger
D-glucose 6-phosphate 4.8 mM, 1.5fold increase in activity at 2 mM fructose 6-phosphate, 2fold increase at 4 mM fructose 6-phosphate, in vitro Aspergillus niger
additional information not activated by 2-oxoglutarate Aspergillus niger
NH4+ NH4+ increases the affinity for fructose 6-phosphate, counteracts the inhibition by ATP Aspergillus niger

General Stability

General Stability Organism
dilution inactivates Aspergillus niger
fructose 6-phosphate stabilizes, not 1 mM ATP or 50% v/v glycerol Aspergillus niger

Inhibitors

Inhibitors Comment Organism Structure
ADP kinetics Aspergillus niger
AMP at high fructose 6-phosphate concentrations, activates at low fructose 6-phosphate concentrations Aspergillus niger
ATP synergistic with citrate Aspergillus niger
citrate strong inhibition; synergistic with ATP; synergistic with NH4+; synergistic with phosphate and AMP Aspergillus niger
additional information not inhibited by cAMP Aspergillus niger
phosphoenolpyruvate
-
Aspergillus niger

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.08
-
ATP pH 7.8, 30°C Aspergillus niger
0.08
-
GTP pH 7.8, 30°C Aspergillus niger

Organism

Organism UniProt Comment Textmining
Aspergillus niger
-
-
-
Aspergillus niger B60
-
-
-

Purification (Commentary)

Purification (Comment) Organism
partial Aspergillus niger

Source Tissue

Source Tissue Comment Organism Textmining
mycelium
-
Aspergillus niger
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
6.1
-
-
Aspergillus niger

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + D-fructose 6-phosphate
-
Aspergillus niger ADP + D-fructose 1,6-bisphosphate
-
?
ATP + D-fructose 6-phosphate
-
Aspergillus niger B60 ADP + D-fructose 1,6-bisphosphate
-
?
GTP + D-fructose 6-phosphate
-
Aspergillus niger GDP + D-fructose 1,6-bisphosphate
-
?
GTP + D-fructose 6-phosphate
-
Aspergillus niger B60 GDP + D-fructose 1,6-bisphosphate
-
?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
assay at Aspergillus niger

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.6 8
-
Aspergillus niger

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.15
-
phosphoenolpyruvate pH 7.8, 30°C Aspergillus niger
0.25
-
citrate pH 7.8, 30°C, at 0.1 mM ATP Aspergillus niger
0.4
-
citrate pH 7.8, 30°C, at 0.5 mM ATP Aspergillus niger