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Literature summary for 2.7.1.11 extracted from

  • Beinhauer, I.; Klee, A.; Schmist, H.; Wegener, G.; Newsholme, E.A.
    Properties of 6-phosphofructokinase from insect flight muscle (1987), Biochem. Soc. Trans., 15, 378-379.
No PubMed abstract available

Activating Compound

Activating Compound Comment Organism Structure
AMP activation Calliphoridae
AMP activation Apis mellifera
AMP activation Locusta migratoria
AMP concomitant with NH4+ and phosphate Locusta migratoria
D-fructose 1,6-bisphosphate activation Locusta migratoria
D-fructose 1,6-bisphosphate activation of flight muscle PFK in the absence of fructose 2,6-bisphosphate Locusta migratoria
NH4+ concomitant with AMP and phosphate Locusta migratoria
phosphate concomitant with NH4+ and AMP Calliphoridae
phosphate concomitant with NH4+ and AMP Apis mellifera
phosphate concomitant with NH4+ and AMP Locusta migratoria

Inhibitors

Inhibitors Comment Organism Structure
ATP
-
Apis mellifera
ATP fructose 2,6-bisphosphate partially reverses inhibition; phosphate and AMP partially reverse inhibition Locusta migratoria
citrate cAMP, ADP or fructose 1,6-bisphosphate restore activity Apis mellifera
citrate cAMP, ADP or fructose 1,6-bisphosphate restore activity Calliphoridae
citrate cAMP, ADP or fructose 1,6-bisphosphate restore activity Locusta migratoria
D-fructose 1,6-bisphosphate 0.02 mM, 50% inhibition at 100 mM fructose 6-phosphate in the absence of fructose 2,6-bisphosphate, inhibition is reversed by fructose 2,6-bisphosphate Apis mellifera
D-fructose 1,6-bisphosphate in the absence of fructose 2,6-bisphosphate Locusta migratoria
D-Glucose 1,6-bisphosphate in the absence of fructose 2,6-bisphosphate Apis mellifera

Organism

Organism UniProt Comment Textmining
Apis mellifera
-
-
-
Calliphoridae
-
blowfly
-
Locusta migratoria
-
locust
-

Purification (Commentary)

Purification (Comment) Organism
partial Apis mellifera
partial Locusta migratoria

Source Tissue

Source Tissue Comment Organism Textmining
muscle
-
Apis mellifera
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + D-fructose 6-phosphate
-
Calliphoridae ADP + D-fructose 1,6-bisphosphate
-
?
ATP + D-fructose 6-phosphate
-
Apis mellifera ADP + D-fructose 1,6-bisphosphate
-
?
ATP + D-fructose 6-phosphate
-
Locusta migratoria ADP + D-fructose 1,6-bisphosphate
-
?